A strong familiality of ankylosing spondylitis through several generations

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To elucidate the familiality of ankylosing spondylitis (AS) in Iceland. METHODS: The Icelandic genealogy database and population-wide data on all living Icelanders diagnosed as h...

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Bibliographic Details
Published in:Annals of the Rheumatic Diseases
Main Authors: Geirsson, Arni Jon, Kristjansson, Kristleifur, Gudbjornsson, Bjorn
Other Authors: Centre for Rheumatology Research, Landspitali, Hringbraut - University Hospital, Reykjavik 101, Iceland.
Format: Article in Journal/Newspaper
Language:English
Published: BMJ 2010
Subjects:
Databases
Genetic
Female
Genetic Predisposition to Disease
Humans
Iceland
Male
Pedigree
Sex Characteristics
Spondylitis
Ankylosing
Online Access:http://hdl.handle.net/2336/115008
https://doi.org/10.1136/ard.2009.125914
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVE: To elucidate the familiality of ankylosing spondylitis (AS) in Iceland. METHODS: The Icelandic genealogy database and population-wide data on all living Icelanders diagnosed as having AS (n=280), who previously had taken part in an epidemiological study on the prevalence of AS in Iceland, were included in the study. Identification of all interpatient relationships in the genealogy database allowed calculation of estimates of the RR for AS in the first-degree relatives (FDRs) to fourth-degree relatives of patients. For each AS proband, 1000 sets of matched Icelandic subjects in the genealogy database were used as controls. RESULTS: FDRs, second-degree and third-degree relatives had RRs of 75.5, 20.2 and 3.5, respectively (all p values <0.0001), indicating a significantly increased risk for relatives of the patients with AS to develop AS, suggesting a strong heritable factor, while the fourth-degree relatives had a RR of 1.04 (p=0.476) for having AS. CONCLUSIONS: Patients with AS in Iceland are significantly more related to each other than to randomly sampled control subjects. This is in agreement with previous reports on the familiality of AS, but the present study has more power and extends over larger familiar cohorts than previously reported.

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