A comparison of genome-scans performed in multicase families with systemic lupus erythematosus from different population groups.

• Published in: Journal of Autoimmunity
• Main Authors: Johanneson, B, Steinsson, K, Lindqvist, A K, Kristjansdottir, H, Gröndal, G, Sandino, S, Tjernström, F, Sturfelt, G, Granados-Arriola, J, Alcocer-Varela, J, Lundberg, I, Jonasson, I, Truedsson, L, Svenungsson, E, Klareskog, L, Alarcón-Segovia, D, Gyllensten, U B, Alarcón-Riquelme, M E
• Other Authors: Department of Genetics and Pathology, Section for Medical Genetics, Biomedical Center, Uppsala University, Uppsala, Sweden.
• Format: Article in Journal/Newspaper
• Language: English
• Published: Academic Press 2010
• Subjects: Ethnic Groups; European Continental Ancestry Group; Female; Genetic Techniques; Genetics; Population; Genome; Human; Humans; Iceland; Indians; North American; Lod Score; Lupus Erythematosus; Systemic; Male; Mexico; Sweden; United States
• Online Access: http://hdl.handle.net/2336/114372; https://doi.org/10.1006/jaut.1999.0305

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Systemic lupus erythematosus is a disease of unknown etiology. Multiple genetic factors are believed to be involved in its pathogenesis. In addition, and due to genetic heterogeneity, these factors and/or their combinations may be different in different ethnic groups, while some might be shared between populations. We have performed genome scans in multicase families from three different population groups, two from Northern Europe, with a high degree of homogeneity, and the third from a recently admixed population of Mexican Mestizos. Although our family material is relatively small, the results presented here show that using family sets from well defined populations are sufficient to detect susceptibility loci for SLE. Our results also reveal the chromosomal regions most likely to contain susceptibility genes for SLE.