Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Pregnancy-induced hypertension may be regarded as a manifestation of endothelial-cell dysfunction. The role of the eNOS gene in the development of a familial pregnancy-induced hypertension...

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Bibliographic Details
Published in:The American Journal of Human Genetics
Main Authors: Arngrimsson, R, Hayward, C, Nadaud, S, Baldursdottir, A, Walker, J J, Liston, W A, Bjarnadottir, R I, Brock, D J, Geirsson, R T, Connor, J M, Soubrier, F
Other Authors: Institute of Medical Genetics, Glasgow University. reynira@rsp.is
Format: Article in Journal/Newspaper
Language:English
Published: Elsevier BV 2010
Subjects:
Adult
Alleles
Chromosomes
Human
Pair 7
Endothelium
Vascular
Female
Genes
Humans
Iceland
Likelihood Functions
Linkage (Genetics)
Lod Score
Matched-Pair Analysis
Microsatellite Repeats
Molecular Epidemiology
Nitric Oxide Synthase
Pre-Eclampsia
Pregnancy
Pregnancy Complications
Cardiovascular
Scotland
Statistics
Nonparametric
Online Access:http://hdl.handle.net/2336/111314
https://doi.org/10.1086/514843
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Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field Pregnancy-induced hypertension may be regarded as a manifestation of endothelial-cell dysfunction. The role of the eNOS gene in the development of a familial pregnancy-induced hypertension was evaluated by analysis of linkage among affected sisters and in multiplex families (n = 50). Markers from a 4-cM region encoding the eNOS gene showed distortion from the expected allele sharing among affected sisters (P = .001-.05), and the statistic obtained from the multilocus application of the affected-pedigree-member method also showed distortion (T[f(P)=sqrt(P)] = 3.53; P < .001). A LOD score of 3.36 was obtained for D7S505 when a best-fitting model derived from genetic epidemiological data was used, and LOD scores of 2.54-4.03 were obtained when various other genetic models were used. Estimates of recombination rate, rather than maximum LOD-score values, were affected by changes in the genetic parameters. The transmission-disequilibrium test, a model-free estimate of linkage, showed strongest association and linkage with a microsatellite within intron 13 of the eNOS gene (P = .005). These results support the localization of a familial pregnancy-induced hypertension-susceptibility locus in the region of chromosome 7q36 encoding the eNOS gene.

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