Small joint involvement in psoriatic arthritis is associated with onycholysis: the Reykjavik Psoriatic Arthritis Study.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: Psoriasis and psoriatic arthritis (PsA) are associated with nail changes. Recent reports suggest that nail changes may be a part of the enthesitis of PsA and that they predict t...

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Bibliographic Details
Published in:Scandinavian Journal of Rheumatology
Main Authors: Love, T J, Gudjonsson, J E, Valdimarsson, H, Gudbjornsson, B
Other Authors: Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Format: Article in Journal/Newspaper
Language:English
Published: Informa Healthcare 2010
Subjects:
Adolescent
Adult
Aged
80 and over
Arthritis
Psoriatic
Chi-Square Distribution
Cross-Sectional Studies
Female
Finger Joint
Health Surveys
Humans
Iceland
Inflammation
Male
Middle Aged
Onycholysis
Patient Selection
Regression Analysis
Severity of Illness Index
Toe Joint
Online Access:http://hdl.handle.net/2336/109935
https://doi.org/10.3109/03009741003604559
Description
Summary:To access publisher full text version of this article. Please click on the hyperlink in Additional Links field OBJECTIVES: Psoriasis and psoriatic arthritis (PsA) are associated with nail changes. Recent reports suggest that nail changes may be a part of the enthesitis of PsA and that they predict the onset of arthritis among patients with psoriasis, but they have not reported on subclasses of nail changes. However, earlier reports suggested that onycholysis is the nail change most strongly associated with PsA. If nail changes in PsA are a sign of enthesitis, they might be associated with small joint disease in general and the objective of this study was to test this hypothesis. METHODS: A total of 154 patients recruited through the Reykjavik Psoriatic Arthritis Study had a joint, skin, and nail evaluation. Associations with small joint disease were tested using univariate analysis, and confirmed in a multivariate model. RESULTS: Onycholysis had a strong association with small joint involvement [odds ratio (OR) 3.42, 95% confidence interval (CI) 1.41-8.92], while other types of nail changes did not. The number of swollen joints and shorter disease duration were also associated with small joint disease. CONCLUSIONS: Onycholysis is associated with small joint disease in PsA. Future studies of PsA should report the subtypes of nail changes. Longitudinal studies are needed to determine whether onycholysis predicts PsA.

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