Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia

Conflicting data from Western European and USA population studies led us to investigate hyperhomocysteinemia (HHcy), the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and thrombotic disease in North Western Russia. Plasma total homocysteine (tHcy) levels, MTHFR C677T genotype, sele...

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Bibliographic Details
Published in:Thrombosis Research
Main Authors: Shmeleva, V M, Kapustin, S I, Papayan, L P, Sobczynska-Malefora, A, Harrington, D J, Savidge, G F
Format: Article in Journal/Newspaper
Language:English
Published: 2003
Subjects:
North-Western Russia
Online Access:https://kclpure.kcl.ac.uk/portal/en/publications/prevalence-of-hyperhomocysteinemia-and-the-mthfr-c677t-polymorphism-in-patients-with-arterial-and-venous-thrombosis-from-north-western-russia(6a916b54-1af7-4248-b17c-4f7ac8f868f1).html
https://doi.org/10.1016/j.thromres.2003.10.004
http://www.scopus.com/inward/record.url?scp=0348048776&partnerID=8YFLogxK
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Summary:Conflicting data from Western European and USA population studies led us to investigate hyperhomocysteinemia (HHcy), the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and thrombotic disease in North Western Russia. Plasma total homocysteine (tHcy) levels, MTHFR C677T genotype, selected life style determinants and haemostatic factor activity were determined in patients with arterial (n = 33), venous (n = 40), arterial + venous (n = 11) thrombosis and healthy controls (17 = 30). We found raised median tHcy levels in all patient groups vs. controls (p15 mumol/l) of 3.9 (0.6-14.3), 4.8 (1.2-18.8) and 15.8 (2.8-87.3) respectively. tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels>30 mumol/l had the MTHFR C677T homozygous substitution. Elevated tHcy levels (p

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