Genomic evidence for the Pleistocene and recent population history of Native Americans

• Published in: Science
• Main Authors: Raghavan, Maanasa, Steinrücken, Matthias, Harris, Kelley, Schiffels, Stephan, Rasmussen, Simon, DeGiorgio, Michael, Albrechtsen, Anders, Valdiosera, Cristina, Ávila-Arcos, María C., Malaspinas, Anna Sapfo, Eriksson, Anders, Moltke, Ida, Metspalu, Mait, Homburger, Julian R., Wall, Jeff, Cornejo, Omar E., Moreno-Mayar, J. Víctor, Korneliussen, Thorfinn S., Pierre, Tracey, Rasmussen, Morten, Campos, Paula F., De Barros Damgaard, Peter, Allentoft, Morten E., Lindo, John, Metspalu, Ene, Rodríguez-Varela, Ricardo, Mansilla, Josefina, Henrickson, Celeste, Seguin-Orlando, Andaine, Malmstöm, Helena, Stafford, Thomas, Shringarpure, Suyash S., Moreno-Estrada, Andrés, Karmin, Monika, Tambets, Kristiina, Bergström, Anders, Xue, Yali, Warmuth, Vera, Friend, Andrew D., Singarayer, Joy, Valdes, Paul, Balloux, Francois, Leboreiro, Ilán, Vera, Jose Luis, Rangel-Villalobos, Hector, Pettener, Davide, Luiselli, Donata, Davis, Loren G., Heyer, Evelyne, Zollikofer, Christoph P E, Ponce De León, Marcia S., Smith, Colin I., Grimes, Vaughan, Pike, Kelly Anne, Deal, Michael, Fuller, Benjamin T., Arriaza, Bernardo, Standen, Vivien, Luz, Maria F., Ricaut, Francois, Guidon, Niede, Osipova, Ludmila, Voevoda, Mikhail I., Posukh, Olga L., Balanovsky, Oleg, Lavryashina, Maria, Bogunov, Yuri, Khusnutdinova, Elza, Gubina, Marina, Balanovska, Elena, Fedorova, Sardana, Litvinov, Sergey, Malyarchuk, Boris, Derenko, Miroslava, Mosher, M. J., Archer, David, Cybulski, Jerome
• Other Authors: Biological and Environmental Sciences and Engineering (BESE) Division, Integrative Systems Biology Lab, Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, Copenhagen, Denmark, Computer Science Division, University of California, Berkeley, Berkeley, CA, United States, Department of Statistics, University of California, Berkeley, Berkeley, CA, United States, Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, United States, Department of Mathematics, University of California, Berkeley, Berkeley, CA, United States, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, Kongens Lyngby, Denmark, Departmentof Biology and Statistics, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA, United States, Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, Denmark, Department of Archaeology and History, La Trobe University, Melbourne, VIC, Australia, Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Drive, Lane Building, Room L331, Stanford, CA, United States, Department of Zoology, University of Cambridge, Downing Street, Cambridge, United Kingdom, Estonian Biocentre, Evolutionary Biology Group, Tartu, Estonia, Department of Evolutionary Biology, University of Tartu, Tartu, Estonia, Institute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA, United States, School of Biological Sciences, Washington State University, Post Office Box 644236, Heald 429, Pullman, WA, United States, Centro de Investigación en Ciencias del Mar y Limnología/Centro Interdisciplinar de Investigação Marinha e Ambiental, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Rua dos Bragas 289, Porto, Portugal, Department of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Avenue, Urbana, IL, United States, Centro Mixto, Universidad Complutense de Madrid, Instituto de Salud Carlos III de Evolución y Comportamiento Humano, Madrid, Spain, Instituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, Mexico City, Mexico, University of Utah, Department of Anthropology, 270 S 1400 E, Salt Lake City, UT, United States, Department of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, Uppsala, Sweden, Acceleration Mass Spectrometry 14C Dating Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, Aarhus, Denmark, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y de Estudios Avanzados, Irapuato, Guanajuato, Mexico, Genetics Institute, University College London, Gower Street, London, United Kingdom, Evolutionsbiologiskt Centrum, Norbyvägen 18D, Uppsala, Sweden, Department of Geography, University of Cambridge, Downing Place, Cambridge, United Kingdom, Centre for Past Climate Change, Department of Meteorology, University of Reading, Earley Gate, Post Office Box 243, Reading, United Kingdom, School of Geographical Sciences, University Road, Clifton, Bristol, United Kingdom, Escuela Nacional de Antropología e Historia, Periférico Sur y Zapote s/n Colonia Isidro Fabela, Tlalpan, Isidro Fabela, Mexico City, Mexico, Instituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico, Dipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, Bologna, Italy, Department of Anthropology, Oregon State University, 238 Waldo Hall, Corvallis, OR, United States, Museum National d'Histoire Naturelle, CNRS, Université Paris 7 Diderot, Paris, France, Anthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, Zürich, Switzerland, Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, Canada, Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, Germany, Department of Earth System Science, University of California, Irvine, Keck Carbon Cycle Accelerator Mass Spectrometry Group, B321 Croul Hall, Irvine, CA, United States, Instituto de Alta Investigación, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, Chile, Departamento de Antropologia, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, Chile, Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, Sao Raimundo Nonato, Brazil, Laboratoire d'Anthropologie Moléculaire et Imagérie de Synthèse UMR-5288, CNRS, Université de Toulouse, Toulouse, France, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk, Russian Federation, Novosibirsk State University, 2 Pirogova Street, Novosibirsk, Russian Federation, Institute of Internal Medicine, Siberian Branch of RAS, 175/1 ul. B. Bogatkova, Novosibirsk, Russian Federation, Novosibirsk State University, Laboratory of Molecular Epidemiology and Bioinformatics, Novosibirsk, Russian Federation, Vavilov Institute of General Genetics, Gubkina 3, Moscow, Russian Federation, Research Centre for Medical Genetics, Moskvorechie 1, Moscow, Russian Federation
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: American Association for the Advancement of Science (AAAS) 2015
• Subjects: Beringia; Siberia
• Online Access: http://hdl.handle.net/10754/594129; https://doi.org/10.1126/science.aab3884

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model. © 2015, American Association for the Advancement of Science. All rights reserved. 098051, European Research Council; European Research Council; 13-06-00670, RFBR, European Research Council; 14-0400725, RFBR, European Research Council; 14-06-00384, RFBR, European Research Council; 261213, ERC, European Research Council; 2R01HG003229-09, NIH, European Research Council; BB/H005854/1, BBSRC, European Research Council; BCS-1025139, NSF, European Research Council; FT0992258, ARC, European Research Council; CONACYT, European Research Council; ERC, European Research Council; DMS-1201234, NSF, European Research Council; ERC-2011-AdG 295733, ERC, European Research Council; R01-AI17892, NIH, European Research Council; R01-GM094402, NIH, European Research Council