The influence of systolic arterial pressure in the first day after systemic thrombolysis on ischemic stroke outcomes and complication rate: a retrospective single-center study

• Published in: Food Processing: Techniques and Technology
• Main Authors: A. R. Avidzba, V. A. Saskin, A. V. Kudryavtsev, M. Yu. Kirov, А. Р. Авидзба, В. А. Саскин, В. А. Кудрявцев, М. Ю. Киров
• Other Authors: The financing was carried out at the expense of the grant of the Russian Science Foundation «Conducting fundamental scientific researches and exploratory scientific researches by small individual scientific groups». № 23-25-10070., Источники финансирования или иной поддержки. Финансирование осуществлялось за счет средств гранта Российского научного фонда «Проведение фундаментальных научных исследований и поисковых научных исследований малыми отдельными научными группами». № 23-25-10070.
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: NEW TERRA Publishing House 2023
• Subjects: артериальное давление; intravenous thrombolysis; arterial pressure; системный тромболизис; Arkhangelsk
• Online Access: https://www.vair-journal.com/jour/article/view/896; https://doi.org/10.24884/2078-5658-2023-20-6-28-34

Introduction. Reperfusion (both pharmacological and interventional) is the cornerstone of acute ischemic stroke (AIS) management. Currently, there are only limited data in the scientific literature regarding the influence of systemic hemodynamic parameters on the recanalization status and complications of AIS.The objective of our study was to assess the relationship between the systemic hemodynamic parameters in the early postreperfusion period and the outcomes of AIS.Materials and methods. For retrospective analysis, data of 292 patients who received intravenous thrombolysis (IVT) at the Arkhangelsk Regional Stroke Center between 2010 and 2021 were collected. The main endpoints were functional outcome, mortality, and symptomatic intracranial hemorrhage (sICH). The success of reperfusion was defined as the neurological improvement by 4 or more points of the NIHSS score within the first 24 hours after the start of IVT.Results. The relationship between mean systolic blood pressure (SBP) during the first 24 hours of IVT and functional recovery was obtained: B = 0.016 (β = 0.096) [95 % CI 0.000 – 0.031] (р = 0.49). The relationship between maximal SBP during the first day of IVT and functional recovery was also determined: B = 0.009 (β = 0.102) [95 % CI 0.001 – 0.018] (p = 0.037). The sICH occurred in nine cases, all of them were in the group without achieving successful reperfusion.Conclusion. The baseline levels of SBP ≥ 160 mm Hg at hospital admission in patients with AIS followed by IVT are accompanied by worse functional outcome and greater odds of death. The neurological improvement with significant decline in the NIHSS score during the first 24 hours after IVT is associated with a decreased risk of sICH. Введение. Реперфузионные методики (как фармакологические, так и интервенционные) являются основой терапии ишемического инсульта (ИИ) в острейшем периоде. На текущий момент в научной литературе существуют только ограниченные данные о влиянии статуса реканализации на параметры системной гемодинамики и исходы ...