Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV, especially among urban population (26.8%) comp...

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Bibliographic Details
Main Authors: Yu. Reshetnikova V., S. Аndreevskaya N., E. Larionova E., Ю. Решетникова В., С. Андреевская Н., Е. Ларионова Е.
Format: Article in Journal/Newspaper
Language:Russian
Published: Publishing house NEW TERRA 2015
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Online Access:https://www.tibl-journal.com/jour/article/view/819
Description
Summary:The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV, especially among urban population (26.8%) compared to rural (13.6%) citizens. When analyzing the drug susceptibility of tuberculous mycobacteria isolated from pulmonary tuberculosis patients it has been found out that multiple drug resistant strains prevailed in the regions (56.8% of all drug resistant strains), and among them in more than a half of cases the strains were resistant not only to HR but to 3-4 additional TB drugs (29.3% of the total number of tested strains), which significantly increases the risk of treatment failure. Исследовано 287 культур микобактерий туберкулеза (МБТ), полученных из клинического материала пациентов ХМКПТД в 2011-2012 гг. У пациентов ХМКПТД показан высокий процент (24,0%) сочетанной инфекции - туберкулез и ВИЧ-инфекция, особенно среди городского населения (26,8%) против сельского (13,6%). При анализе лекарственной чувствительности МБТ, выделяемых у больных туберкулезом легких, показано, что в регионе преобладали штаммы с множественной лекарственной устойчивостью (56,8% от всех штаммов с лекарственной устойчивостью), причем среди них более чем в половине случаев (84/125, 67,2%) выявляли штаммы МБТ, устойчивые, кроме HR, еще к 3-4 противотуберкулезным препаратам (29,3% от общего числа исследованных штаммов), что существенно повышает риск неэффективного лечения.