SIMULATION OF EPIDEMIC TRANSMISSION OF МYCOBACTERIUM TUBERCULOSIS IN THE SAKHA REPUBLIC (YUKUTIA )

Goal: reconstruction of epidemic transmission of Beijing genotype of Mycobacterium tuberculosis on the territory with limited migration based on the comparative study of 153 isolates isolated from patients of different generations in theSakhaRepublic (Yakutia).Materials and methods. The structure of...

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Bibliographic Details
Published in:Tuberculosis and Lung Diseases
Main Authors: S. N. Zhdаnovа, O. B. Ogаrkov, M. K. Vinokurovа, G. I. Аlekseevа, A. F. Krаvchenko, E. D. Sаvilov, С. Н. Жданова, О. Б. Огарков, М. К. Винокурова, Г. И. Алексеева, А. Ф. Кравченко, Е. Д. Савилов
Format: Article in Journal/Newspaper
Language:Russian
Published: Медицинские знания и технологии 2017
Subjects:
Beijing
MIRU-VNTR
epidemic genotypes
эпидемические генотипы
Sakha
Sakha Republic
Yakutia
Саха
Якути*
Якутия
Online Access:https://www.tibl-journal.com/jour/article/view/1022
https://doi.org/10.21292/2075-1230-2017-95-7-40-47
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Summary:Goal: reconstruction of epidemic transmission of Beijing genotype of Mycobacterium tuberculosis on the territory with limited migration based on the comparative study of 153 isolates isolated from patients of different generations in theSakhaRepublic (Yakutia).Materials and methods. The structure of Mycobacterium tuberculosis population was described and analyzed through MIRU-VNTR-genotyping, subtyping of the parts of RD105/RD207 genome, pattern classification as per clonal pattern of Merker M. et al (2015), and phylogenetic simulation.Results. It was found out that highly transmissive subtypes of Beijing genotype having a high potential of developing drug resistance was confidently more prevalent (χ2 = 8.3, p < 0.01) among younger people (born after 1990) compared to the older generation (born before 1959). It was also found out that during previous five decades a certain shift occurred in the structure of M. tuberculosis population.Conclusion. The obtained data confirm the hypothesis that epidemic sybtypes ofBeijing genotype were brought to the territory of theSakhaRepublic (Yakutia) fairly recently (approximately fifty years ago) compared to the other regions ofRussia. Цель: реконструкция эпидемического распространения штаммов генотипа Beijing Mycobacterium tuberculosis на территории с ограниченными миграционными событиями на основе сравнительного изучения 153 изолятов, полученных от больных разных поколений из Республики Саха (Якутия).Материалы и методы. Путем MIRU-VNTR-генотипирования, субтипирования по участкам генома RD105/RD207, классификации паттернов по клональным комплексам Merker M. et al. (2015) и филогенетического моделирования была описана и проанализирована структура популяции Mycobacterium tuberculosis. Результаты. Показано, что высокотрансмиссивные субтипы генотипа Beijing, несущие высокий потенциал формирования антибиотикорезистентности, значимо чаще (χ2 = 8,3, p < 0,01) встречаются у молодых (после 1990 года рождения), чем в старшем поколении (до 1959 года рождения). Определен сдвиг в ...

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