Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes
Abstract Ala-Pro (AP), Ile-Pro-Ala (IPA) and Ile-Pro-Ala-Val-Phe (IPAVF) as DPP-IV inhibitory peptides were purified from Antarctic krill protein hydrolysate (AKH). Diabetic zebrafish model was rapidly induced with combination of high glucose immersing and cholesterol diet for evaluation the three D...
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Sociedade Brasileira de Ciência e Tecnologia de Alimentos
2021
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ftjscielo:oai:scielo:S0101-20612021005008205 2023-05-15T13:41:51+02:00 Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes JI,Wei ZHANG,Chaohua SONG,Cai JI,Hongwu 2021-01-01 text/html http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021005008205 en eng Sociedade Brasileira de Ciência e Tecnologia de Alimentos 10.1590/fst.58920 info:eu-repo/semantics/openAccess Food Science and Technology n.ahead 2021 DPP-IV inhibitory peptides diabetic zebrafish glycemic level Antarctic krill hydrolysate info:eu-repo/semantics/article 2021 ftjscielo 2021-03-11T11:28:17Z Abstract Ala-Pro (AP), Ile-Pro-Ala (IPA) and Ile-Pro-Ala-Val-Phe (IPAVF) as DPP-IV inhibitory peptides were purified from Antarctic krill protein hydrolysate (AKH). Diabetic zebrafish model was rapidly induced with combination of high glucose immersing and cholesterol diet for evaluation the three DPP-IV inhibitory peptides activity. Physiochemical indexes including DPP-IV activity, glucose, triglyceride and cholesterol; the relative gene (insa, glucagon and pck1) expressions levels were detected. The results showed that after 15 days of peptides treatment, the physiochemical index levels of peptide groups were significantly higher than that of negative control and showed dose-dependent effect. The insa gene expression level would be increased with the enhancement of peptide concentration, whereas gene expression levels of glucagon and pck1 would be decreased. These results indicated that three peptides all had hypoglycemic effects in different degree. It suggested the potential of AKH containing DPP-IV inhibitory peptides could be as functional food supplement to treat diabetes. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill SciELO Brazil (Scientific Electronic Library Online) Antarctic |
institution |
Open Polar |
collection |
SciELO Brazil (Scientific Electronic Library Online) |
op_collection_id |
ftjscielo |
language |
English |
topic |
DPP-IV inhibitory peptides diabetic zebrafish glycemic level Antarctic krill hydrolysate |
spellingShingle |
DPP-IV inhibitory peptides diabetic zebrafish glycemic level Antarctic krill hydrolysate JI,Wei ZHANG,Chaohua SONG,Cai JI,Hongwu Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
topic_facet |
DPP-IV inhibitory peptides diabetic zebrafish glycemic level Antarctic krill hydrolysate |
description |
Abstract Ala-Pro (AP), Ile-Pro-Ala (IPA) and Ile-Pro-Ala-Val-Phe (IPAVF) as DPP-IV inhibitory peptides were purified from Antarctic krill protein hydrolysate (AKH). Diabetic zebrafish model was rapidly induced with combination of high glucose immersing and cholesterol diet for evaluation the three DPP-IV inhibitory peptides activity. Physiochemical indexes including DPP-IV activity, glucose, triglyceride and cholesterol; the relative gene (insa, glucagon and pck1) expressions levels were detected. The results showed that after 15 days of peptides treatment, the physiochemical index levels of peptide groups were significantly higher than that of negative control and showed dose-dependent effect. The insa gene expression level would be increased with the enhancement of peptide concentration, whereas gene expression levels of glucagon and pck1 would be decreased. These results indicated that three peptides all had hypoglycemic effects in different degree. It suggested the potential of AKH containing DPP-IV inhibitory peptides could be as functional food supplement to treat diabetes. |
format |
Article in Journal/Newspaper |
author |
JI,Wei ZHANG,Chaohua SONG,Cai JI,Hongwu |
author_facet |
JI,Wei ZHANG,Chaohua SONG,Cai JI,Hongwu |
author_sort |
JI,Wei |
title |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_short |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_full |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_fullStr |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_full_unstemmed |
Three DPP-IV inhibitory peptides from Antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
title_sort |
three dpp-iv inhibitory peptides from antarctic krill protein hydrolysate improve glucose levels in the zebrafish model of diabetes |
publisher |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publishDate |
2021 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612021005008205 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Food Science and Technology n.ahead 2021 |
op_relation |
10.1590/fst.58920 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1766159139579363328 |