Specific features of the lymphocyte enzyme status in newborn infants with the hypotrophic type of intrauterine growth retardation

• Published in: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
• Main Authors: V. P. Novitskaya, V. L. Gritsinskaya, В. П. Новицкая, В. Л. Грицинская
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2016
• Subjects: Якутия; intrauterine growth retardation; enzymes; lymphocytes; Yakutia; задержка внутриутробного развития; ферменты; лимфоциты; Yakutsk; Якути*
• Online Access: https://www.ped-perinatology.ru/jour/article/view/324; https://doi.org/10.21508/1027-4065-2016-61-3-46-50

Objective: to reveal the specific features of the lymphocyte enzyme status in newborn infants with hypotrophic type of intrauterine growth retardation under the conditions of Yakutia.Subjects and methods. A total of 137 full-term newborns (including 28 babies with intrauterine growth retardation) whose parents were Yakutsk newcomers were examined on 1, 3 and 5 days of life. The cytochemical activity of lymphocyte enzymes, by determining the level of and time course of changes in succinate dehydrogenase (SDH), glycerol-3-phosphate dehydrogenase (GPDH), lactate dehydrogenase (LDH) and its aerobic isoenzyme (LDH-H), NADFH2-diaphorase, monoamine oxidase (MAO), and acid phosphatase (AP), were analyzed.Results. It was ascertained that the activity of SDH, GPDH, and LDH was higher on 5 day of life and that of NADFH2-diaphorase was lower in infants with intrauterine growth retardation than in apparently healthy neonates. Desynchronosis of the metabolic pathways was established in the dynamics of early ontogenesis.Conclusion. It is necessary to rationally correct standard treatment regimens, by taking into account the found metabolic features in infants with intrauterine growth retardation under the conditions of Yakutia. Цель исследования: выявить особенности ферментного статуса лимфоцитов крови новорожденных детей с гипотрофическим вариантом задержки внутриутробного развития в условиях Якутии.Обследованы 137 доношенных новорожденных детей пришлого населения г. Якутска в 1, 3 и 5-е сутки жизни, из них 28 детей с задержкой внутриутробного развития. Проведен анализ цитохимической активности ферментов лимфоцитов крови с опре- делением уровня и динамики сукцинатдегидрогеназы (СДГ), глицерол-3-фосфатдегидрогеназы (ГФДГ), лактатдегидрогеназы (ЛДГ) и ее аэробного изофермента (Н-ЛДГ), НАДФ.Н2-диафоразы, моноаминоксидазы (МАО) и кислой фосфатазы (КФ). Установлено, что у детей с задержкой внутриутробного развития в лимфоцитах крови повышена активность СДГ, ГФДГ, ЛДГ на 5-е сутки жизни и снижена активность НАДФ.Н2-диафоразы в ...