Hypoglycemic effect of the juice of Passiflora tripartita var. mollisima “pur pur” compared with metformin in Rattus rattus var. albinus
The juice of Plassiflora tripartita var. mollisima "pur pur" has a high content of phenols and flavonoids with antioxidant capacity and potential hypoglycemic effect. Therefore, a quasi-experimental, analytical study, with pre and post test, was carried out to evaluate the hypoglycemic eff...
| Main Authors: | , , |
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| Format: | Article in Journal/Newspaper |
| Language: | Spanish |
| Published: |
Seguro Social de Salud
2023
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| Online Access: | https://rpmi.pe/index.php/rpmi/article/view/722 https://doi.org/10.26722/rpmi.2023.v8n2.722 |
| Summary: | The juice of Plassiflora tripartita var. mollisima "pur pur" has a high content of phenols and flavonoids with antioxidant capacity and potential hypoglycemic effect. Therefore, a quasi-experimental, analytical study, with pre and post test, was carried out to evaluate the hypoglycemic effect of P. tripartita juice compared to metformin in Rattus rattus var. albinus with diabetes mellitus provoked with alloxane. Juice 250 mg/kg and metformin 14 mg/kg were administered; and glycemia was evaluated on the fourth and tenth day. In the group with P. tripartita juice, the postprandial value was 329.4 ±50.0 mg/mL and after 4 days of treatment, it was reduced to 234.0 ±38.9 mg/mL; and at 10 days at 141.9 ±30.3 mg/mL. In the group with metformin, the postprandial value was 353.5 ±47.6 mg/mL and after 4 days of treatment, it was reduced to 244.5 ±36.5 mg/mL; and at 10 days at 113.9 ±20.1 mg/mL. In conclusion, the treatment applied with P. tripartita juice had a hypoglycemic effect, but less than metformin. Introducción:El zumo de Plassiflor tripartita var. mollisima“pur pur” presenta alto contenido de fenoles y flavonoides con capacidad antioxidante y potencial efecto hipoglicémico. Objetivo:Evaluar el efecto hipoglicemiante del zumo de P. tripartita var. mollisima“pur pur” comparado con la metformina en Rattus rattus var. albinuscon diabetes mellitus provocadas con aloxano. Métodos: Se realizó un estudio cuasi experimental, analítico, longitudinal, prospectivo, con pre y post prueba. Se indujo a ratas albinas a presentar hiperglicemia con aloxano monohidrato de 100mg/kg (vía intraperitoneal). El zumo se aplicó en una dosis al día de 250 mg/kg (vía oral) por 10 días. Se administró 14 mg/kg de metformina (vía oral) también a dosis única. La glicemia se evaluó por tiras reactivas y analizadas con el glucómetro ACCUCHEK, en el cuarto y décimo día después de la administración de aloxano. Se analizaron los datos con las pruebas ANOVA, post hocde Tukey y la prueba de diferencia mínima significativa (DMS), Resultados: La ... |
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