Hypotensive effect of Linum usitatissimum flour versus enalapril in Rattus rattus var. albinus

• Main Authors: Zarate Campos, Dayana Shery, Llaque Sánchez, María Rocío Del Pilar, Polo Gamboa, Jaime Abelardo, Yupari Azabache, Irma
• Format: Article in Journal/Newspaper
• Language: Spanish
• Published: Seguro Social de Salud 2023
• Subjects: Lino; Hipertensión; Enalapril; Antihipertensivos; Flax; Hypertension; Antihypertensive Agents; Rattus rattus
• Online Access: https://rpmi.pe/index.php/rpmi/article/view/720; https://doi.org/10.26722/rpmi.2023.v8n2.720

Hypertension is a prevalent condition worldwide, and natural alternatives for its management are constantly sought. The aim of the study was to evaluate the hypotensive effect of Linum usitatissimum(LU) flour compared to enalapril in Rattus rattus var. albinus. This was a preclinical experimental study, conducted on three groups of 5 rats with 200mg/Kg/day of LU (group 1), 10mg/Kg/day of enalapril (group 2), and distilled water (group 3). Systolic (SBP) and diastolic blood pressure (DBP) were measured at baseline, on the fifth and seventh day (mmHg). Means were compared using Student's t-test and ANOVA. In group 1: the baseline SBP was 173.8; 56.4 (p=0.148) on the fifth day and 136.6 (p=0.021) on the seventh day. The baseline DBP in group 1 was 122.2; 120.2 (p=0.713) on the fifth day and 107.2 (p=0.105) on the seventh day. The comparison of the means of the differences on the fifth day showed that the effect of group 1 on SBP and DBP was less than that of group 2. It is concluded that linseed flour has a slight systolic hypotensive effect in Rattus rattus var. albinus, but less than enalapril. Introducción: La linaza es un alimento con alto contenido de fibra, ácido α-linolénico y lignanos, con múltiples beneficios sobre la presión arterial elevada. Objetivo: Evaluar el efecto hipotensor de la harina de Linum usitatissimum linaza comparado con enalapril en Rattus rattus var. albinus, hipertensas. Materiales y métodos: Se realizó un estudio experimental analítico de pre y post prueba, para ello se realizó la medición de la presión arterial sistólica (PAS) y presión arterial diastólica (PAD). Se clasificaron tres grupos de tratamiento con 5 roedores, el Grupo 1 con harina de Linum usitatissimum (3 ml/kg/día/VO) por 07 días, Grupo 2 con enalapril 10 mg/Kg y el Grupo 3 con agua destilada. Se realizó la prueba estadística ANOVA y se determinó el mejor tratamiento con una prueba Post ANOVA Tukey. Resultados: En el caso de la PAS, en el Grupo 1 con harina de linaza (Linum usitatissimum) el basal fue 173,8 mmHg y ...