Hypoglycemic effect of infusion of Psoralea glandulosa “cullen” whole plant in normoglycemic rats.

• Main Author: Ramírez Verástegui, Jorves
• Format: Article in Journal/Newspaper
• Language: Spanish
• Published: Seguro Social de Salud 2016
• Subjects: Plantas Medicinales; Hipoglucemiantes; Experimentación Animal; Modelos Animales; Plants; Medicinal; Hypoglycemic Agents; Animal Experimentation; Models; Animal; Rattus rattus
• Online Access: https://rpmi.pe/index.php/rpmi/article/view/679; https://doi.org/10.26722/rpmi.2016.12.14

Objective: The hypoglycemic effect of the infuso of Psoralea glandulosa “cullen” whole plant was determinated in normoglycemic Rattus rattus var. albinus.Materials and methods: 36 normogly-cemic rats was divided into three groups; Group I: Administration to 10 mL / kg infuso; Group II: Administration to 30 mL / kg infuso; and Group III: Administration of sterile distilled water (control). The operation was performed in four days. The basal glycemia was measured at 60 minutes and 120 minutes after administration of the product. Results: We found that on 1st and 4th day were significant differences in blood glucose measurements at 60 and 120 min compared with baseline. In the evaluation of blood glucose levels over the time; we’ve found significant differences between the three groups (p = 0.04). Also, we’ve found significant differences between applying a dose of 10 mL / kg and a dose of 30 mL / kg (p <0.001). The dose of 30 mL / kg has shown an average variation of glycemia levels of 7.89 ± 2.92%. Conclusions: hypoglycemic effect was found with the use of infused whole plant Psoralea globulosa “cullen” to 30 mL / kg in albino Rattus rattus var normoglycemic. Objetivo. Determinar el efecto hipoglucemiante del infuso de la planta total de Psoralea glandulosa“cullen” en Rattus rattus var albinus. Materiales y métodos. Se dividieron a 36 ratas albinas nor-moglicémicas en tres grupos de 12; Grupo I: administración de infuso a 10 mL/kg peso; Grupo II: administración de infuso a 30 mL/kg peso, y Grupo III: control al cual se administró agua destilada estéril. La intervención se realizó en cuatro días, en los cuales se midió la glicemia basal, a 60 y 120 min después de la administración del producto. Resultados. Se encontró que en el 1.° y 4.° día hubo diferencias significativas en las mediciones de glicemia a los 60 y 120 min comparadas con el basal del día correspondiente. Al evaluar el comportamiento de los valores de glicemia en el tiempo; se obtuvieron diferencias significativas entre los tres grupos (p=0,04). ...