Effect of Tropaeolum tuberosum “mashua” aqueous extract in memory impairment and lipid peroxidation induced by fluoxetin in ooferectomized Rattus rattus var albinus

• Main Authors: Cruz Olivera, Jocelin, Valverde Gomez, Milton Eder, Ybañez Julca, Roberto
• Format: Article in Journal/Newspaper
• Language: Spanish
• Published: Seguro Social de Salud 2017
• Subjects: Peroxidación de Lípido; Experimentación Animal; Plantas Medicinales; Lipoperoxidation; Animal Experimentation; Medicinal plants; Blanco; Rattus rattus
• Online Access: https://rpmi.pe/index.php/rpmi/article/view/604; https://doi.org/10.26722/rpmi.2017.22.53

Objective. The objective of this research was to demonstrate the effect of aqueous extract of Tropaeolum tuberosum “Mashua” on memory impairment and lipid peroxidation induced liver fluoxetine and Rattus rattus var. albinus ooforectomizadas. Material and methods. Experimental research. This research was conducted in five groups, making a total of 29 specimens of the species females, in which only 24 of them were induced them to a process of menopause (ovariectomy). The groups were divided into: naïve, control which were administered fluoxetine 20 mg/kg at a concentration of 0.15 % for three initial weeks, problem 1 and 2, at a dose of 1 g / Kg at a concentration of 10 % and 2 g/kg at 20% concentration respectively.Results. Significant differences were found in the group receiving the 10%(1 g/kg. Tropaeolum tuberosumextract compared to that received only Fluoxetine (p = 0.002). There were no significant differences between groups or intra-group in the cognitive evaluation. Conclusions. The aqueous extract of 10% Tropaeolum tuberosum in doses of 1 g/kg has a decrease in the lipoperoxidation induced by Fluoxetine in Rattus rattus var. albinusooforectomized. Objetivo. Evaluar el efecto del extracto acuoso de Tropaeolum tuberosum “mashua” sobre el deterioro de la memoria y la lipoperoxidación inducida por fluoxetina en higado en Rattus rattus var. albinus ooferectomizadas. Materiales y Métodos. Estudio experimental. Se usaron 29 animales de experimentación intervenidos por seis semanas divididos en cinco grupos: Blanco (n=5), que no recibió ninguna intervención; Control (n=6), ratas con ooforectomia bilateral; Patron (n=6), ratas ooforectomizadas a las cuales se les administró 20 mg/kg por vía oral de una solución de 0,15 % de fluoxetina (inductor de lipoperoxidación) por tres semanas, una vez al día; y finalmente los grupos Problema I (n=6) y II (n=6) que recibieron la misma intervención del grupo Patron por tres semanas y, posteriormente, se les administró el extracto de Tropaeolum tuberosum “mashua” a una dosis ...