Effect of lyophilisate of the fruit Azadirachta indica a. Juss on glycemia in rats

• Main Authors: RODRIGUEZ VEGA, JUAN LUIS, GARCIA ISHIMINE, RICHARD FREDY, MEJIA PINEDO, DAVIS ALBERTO, LORA LOZA, MIRYAM GRISELDA, CALDERON MUNDACA, WILMER LEONCIO
• Format: Article in Journal/Newspaper
• Language: Spanish
• Published: Editorial Ciencias Médicas 2021
• Subjects: Glycemia; Azadirachta indica; rats; Glicemia; ratas; Rattus rattus
• Online Access: https://revibiomedica.sld.cu/index.php/ibi/article/view/1912

Introduction: Glycemia is a preponderant characteristic of certain chronic metabolic syndromes prevalent in the world and constitutes a public health problem, where Azadirachta indica has traditionally been used to normalize blood glucose levels for more than four thousand years. as a therapeutic alternative.Objective: To determine the effect on glycemia in experimental diabetes in Rattus rattus Var Albinus of the freeze-dried aqueous extract of the fruit Azadirachta indica A. Juss, “Neem”, at 200 mg and 400 mgMethod: An experimental, prospective, longitudinal design was used with a sample of 30 male rats divided into 3 groups that were experimentally induced diabetes with streptozotocin, two groups were administered two doses of lyophilized aqueous Neen extract and the third one with water ad libitum as placebo.Results: On day 1 he had an average glucose concentration of 283.7 ± 7.7 mg / dl; For the 7th day, a concentration of 179.5 ± 6.4 mg / dl was observed; for the 14th day, the average glucose concentration was 91.1 ± 9.1 mg / dl; and for day 21 an average glucose concentration of 84.4 ± 11.6 mg / dl was obtained, finally a concentration for day 28 the average glucose of 60.2 ± 4.9 mg / dl.Conclusions: The lyophilized extract of the Neem fruit has a hypoglycemic effect at doses of 200 mg and 400 mg. Introducción La glicemia es una característica preponderante de ciertos síndromes metabólicos crónicas prevalentes en el mundo y constituye un problema de salud pública, donde para normalizar los niveles de glucosa en la sangre se ha empleado tradicionalmente la Azadirachta indica desde hace más de cuatro mil años., como alternativa terapéutica.Objetivo. Determinar el efecto sobre la glicemia en diabetes experimental en Rattus rattus Var Albinus del extracto acuoso liofilizado del fruto Azadirachta indica A. Juss, “Neem”, a 200 mg y 400 mgMétodo. Se empleó un diseño experimental, prospectivo, longitudinal con una muestra de 30 ratas machos divididas en 3 grupos a quienes se les indujo diabetes ...