Factors related to mortality in patients with chronic obstructive pulmonary disease in Colombian population

• Main Authors: Tuta-Quintero, Eduardo, Bastidas, Alirio R., Giraldo-Cadavid, Luis F., Echeverri, Juliana, Botero, Juan D., Villarreal, Valentina, Zambrano, Camila, Rabe, Valeria, Hernández, Juan, Tavera, Daniel, Acosta, Juan, Martínez, Ángela, Granados, Carlos, Nieto, María, Román, Sergio E., Achry , William A., Guezguan-Pérez, Jonathan, Prieto, Paula, Parra-Cárdenas, Diana
• Format: Article in Journal/Newspaper
• Language: Spanish
• Published: Instituto Nacional de Salud 2024
• Subjects: Pulmonary disease; chronic obstructive; mortality; risk factors; observational study; enfermedad pulmonar obstructiva crónica; mortalidad; factores de riesgo; estudio observacional; Bajos; Arctic
• Online Access: https://revistabiomedica.org/index.php/biomedica/article/view/7140

Introduction. Data in low- and middle-income countries on mortality and its related risk factors in patients with chronic obstructive pulmonary disease are limited.Objective. To identify the incidence of death and its relationship with variables in a Colombian population during 12 months of follow-up.Materials and methods. We carried out a retrospective study in subjects diagnosed with chronic obstructive pulmonary disease in a third-level hospital in Colombia. Odds ratios were calculated using multivariable logistic regression analysis with the outcome variable “mortality at 12 months”.Results. We included 524 patients, 18.1% (95 / 524) died. The average age was 69.7 (SD = 8.92), and 59.2% (310 / 524) were women. The variables associated with mortality were age (OR = 6.54; 95% CI = 3.65-11.36; p < 0.001), years of exposure to wood smoke (OR = 4.59; 95% CI = 1.64-2.82; p = 0.002), chronic heart failure (OR = 1.81; 95% CI = 1.13-2.91; p = 0.014), cerebrovascular disease (OR = 3.35; 95% CI = 1.04-10.75; p = 0.032), and chronic kidney disease (OR = 6.96; 95% CI = 1.15-41.67; p=0.015). When adjusting the variables in the multivariate analysis, only an association was found for sex (OR = 1.55; 95% CI = 0.95-2.54; p = 0.008) and age (OR = 5.94; 95% CI = 3.3-10.69; p < 0.001).Conclusion. Age, years of exposure to wood smoke, chronic heart failure, and cerebrovascular and chronic kidney disease were the clinical variables associated witha fatal outcome. However, age and sex were the only variables related to mortality when adjusted for confounding factors. Introducción. En los países de medianos y bajos ingresos, los datos sobre la mortalidad y los factores de riesgo en pacientes con enfermedad pulmonar obstructiva crónica son limitados.Objetivo. Identificar la incidencia de muerte y sus variables relacionadas en una población colombiana durante 12 meses de seguimiento.Materiales y métodos. Se llevó a cabo un estudio retrospectivo de sujetos con diagnóstico de enfermedad pulmonar obstructiva crónica en una ...