An experience of vaccination against pneumococcal infection of adults at Krasnoyarsk krai

• Published in: PULMONOLOGIYA
• Main Authors: I. V. Demko, E. E. Korchagin, N. V. Gordeeva, A. Yu. Kraposhina, I. A. Solov'eva, И. В. Демко, Е. Е. Корчагин, Н. В. Гордеева, А. Ю. Крапошина, И. А. Соловьева
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Pulmonology 2017
• Subjects: хронические заболевания; Pneumo-23; Prevenar-13; community-acquired pneumonia; conjugated pneumococcal vaccines; chronic diseases; Пневмо-23; Превенар-13; внебольничная пневмония; конъюгированные пневмококковые вакцины; Krasnoyarsk Krai
• Online Access: https://journal.pulmonology.ru/pulm/article/view/814; https://doi.org/10.18093/0869-0189-2017-27-1-21-28

The aim of the study was to investigate efficacy of specific prevention of pneumococcal infection in high-risk group patients living at Krasnoyarsk krai. Methods. The study involved 12,080 patients with a high risk of pneumococcal infection including patients with chronic lung diseases, chronic heart failure (CHF) and diabetes mellitus. A special questionnaire was developed which included medical history for the previous 1 year and for 1 year after the vaccination. Results. CHF was diagnosed in 41.08% of patients, diabetes was diagnosed in 28.44%, chronic lung diseases were diagnosed in 30.07%; 2.4% of patients had pneumonia. PCV13 vaccine (Prevenar 13) was used in 9,986 patients (82.67%) including 5,070 patients (41.97%) vaccinated against flu and pneumococcus simultaneously. PPV23 (Pneumo-23) vaccine was used in 1,967 patients (16.28%) including 1,181 patients (9.83%) vaccinated against flu and pneumococcus simultaneously. Due to the broad-scale vaccination against pneumococcal infection, exacerbation rate reduced trice, number of hospitalisations related to exacerbations reduced by 11.5 times, morbidity of pneumonia reduced by 4.8 times, morbidity of acute respiratory infections and flu reduced by 6.6 times. Conclusion. The results confirmed high efficacy and safety of 13-valent conjugate pneumococcal vaccine and 23-valent polysaccharide pneumococcal vaccine. The vaccination allowed reducing morbidity of respiratory infection and decrease number of hospitalisations due to exacerbations of chronic diseases. Целью исследования явилось изучение эффективности специфической профилактики пневмококковой инфекции у лиц групп риска, проживающих в Красноярском крае. Материалы и методы. Обследованы лица (n = 12 080) групп риска – с хроническими заболеваниями легких (ХЗЛ), хронической сердечной недостаточностью (ХСН) и сахарным диабетом (СД). Для оценки клинической эффективности вакцинации разработана специальная анкета, включающая оценку анамнеза в течение 1 года, предшествующего вакцинации, и анамнез основного ...