Invasive Haemophilus influenzae disease in Northwestern Ontario First Nations communities: Case Series

We present clinical and microbiological data of 5 pediatric cases of invasive Haemophilus influenzae disease, which occurred over a period of 10 months in the service area of a regional hospital of Northwestern Ontario. Four cases of invasive H. influenzae type a (Hia) disease presented either as me...

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Bibliographic Details
Published in:International Journal of Case Reports
Main Author: Chelsea J. Kubinec MSci1, Len Kelly MD MClinSci2, Sarah Byce MD, MSci1, Raymond S.W. Tsang MMedSc PhD3, Marina Ulanova MD PhD4
Format: Article in Journal/Newspaper
Language:English
Published: eSciPub LLC 2020
Subjects:
Haemophilus influenzae
invasive disease
First Nations communities
First Nations
Online Access:https://escipub.org/index.php/IJCR/article/view/662
https://doi.org/10.28933/ijcr-2020-05-2805
Description
Summary:We present clinical and microbiological data of 5 pediatric cases of invasive Haemophilus influenzae disease, which occurred over a period of 10 months in the service area of a regional hospital of Northwestern Ontario. Four cases of invasive H. influenzae type a (Hia) disease presented either as meningitis, non-complicated and complicated pneumonia, or soft tissue infection in children between 7 months and 6 years of age. Although the cases were from different communities with no known common exposure, the Hia isolates demonstrated similar phenotypic and genotypic characteristics. One case of invasive disease due to nontypeable H. influenzae (NTHi) presented as chorioamnionitis in an adolescent. The data emphasize the significance of Hia and NTHi as a cause of serious disease in Indigenous communities.

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