The effect of Locally Applied Bacillus safensis Strain 440-1 from Antarctic Soil on the Course of Experimental Wound Staphylococcal Infection

Relevance. Infections caused by methicillin-resistant strains of Staphylococcus aureus are an urgent problem of hospital epidemiology, and control measures involve the development of new antimicrobials. Probiotics based on bacterial strains isolated fro natural habitats are considered promising mean...

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Bibliographic Details
Published in:Epidemiology and Vaccinal Prevention
Main Authors: B. I. Aslanov, V. V. Kolodzhieva, E. A. Lebedeva, I. A. Tumanyan, Yu. D. Won, A. S. Mokhov, A. A. Dolgiy, A. E. Goncharov, Б. И. Асланов, В. В. Колоджиева, Е. А. Лебедева, И. А. Туманян, Ю. Д. Вон, А. С. Мохов, А. А. Долгий, А. Е. Гончаров
Format: Article in Journal/Newspaper
Language:Russian
Published: «Numicom» LLC 2024
Subjects:
биопроспектинг
probiotics
experimental wound infection
MRSA
antibiotic resistance
bioprospecting
экспериментальная раневая инфекция
антибиотикорезистентность
Antarctic
Antarc*
Online Access:https://www.epidemvac.ru/jour/article/view/1906
https://doi.org/10.31631/2073-3046-2023-22-6-66-71
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Summary:Relevance. Infections caused by methicillin-resistant strains of Staphylococcus aureus are an urgent problem of hospital epidemiology, and control measures involve the development of new antimicrobials. Probiotics based on bacterial strains isolated fro natural habitats are considered promising means of combating MRSA.Aims. To test the possibility of using the Bacillus safensis 440-1 strain isolated from Antarctic soil. as an antibacterial agent for the treatment of experimental staphylococcal infection.Purpose of the study – check the possibility of using the Bacillus safensis 440-1 strain, isolated from Antarctic soil, as a topical antibacterial agent for the treatment of experimental staphylococcal infection.Material and methods. The potential virulence of Bacillus safensis strain 440-1 was studied on a mouse peritonitis model, and its activity against the methicillin-resistant Staphylococcus aureus SA776 test strain was studied on a localized wound infection model.Results and discussion. Our study demonstrated the safety of the tested strain due intraperitoneal use. We found that the use of the studied strain reduces the staphylococci amount in wounds from the third day from the start of the study to the end of the observation period, without aggravating the course of the infection.Conclusion. Bacillus safensis strain is a promising potential probiotic and it can be used as a part of complex antiseptic or disinfectant after additional studies aimed at developing an optimal mode of its use. Введение. Инфекции, обусловленные метициллин-резистентными штаммами Staphylococcus aureus (MRSA), являются актуальной проблемой госпитальной эпидемиологии, а меры их сдерживания предполагают разработку новых антимикробных препаратов. Пробиотики на основе штаммов бактерий, выделенных из природных источников, считаются перспективными средствами борьбы с MRSA.Цель. Проверить возможность использования штамма Bacillus safensis 440-1, выделенного из антарктической почвы, в качестве антибактериального средства местного ...

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