Lipase-Catalyzed Dynamic Kinetic Resolution of Chiral Amines: Use of Palladium as the Racemization Catalyst

The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77% (ee = 99%).

Bibliographic Details
Published in:CHIMIA
Main Authors: Reetz, Manfred T., Schimossek, Klaus
Format: Article in Journal/Newspaper
Language:English
Published: Swiss Chemical Society 1996
Subjects:
Antarc*
Antarctica
Online Access:https://www.chimia.ch/chimia/article/view/1996_668
https://doi.org/10.2533/chimia.1996.668
Description
Summary:The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77% (ee = 99%).

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