Features of Coronary Atherosclerosis in Patients with Coronary Artery Disease Residing in the Far North

• Published in: The Canadian field-naturalist
• Main Authors: R. B. Utegenov, S. S. Sapozhnikov, M. G. Kashtanov, A. A. Shadrin, I. S. Bessonov, Р. Б. Утегенов, С. С. Сапожников, М. Г. Каштанов, А. А. Шадрин, И. С. Бессонов
• Other Authors: the study was carried out within the state task of the Ministry of Education and Science of the Russian Federation (performer – Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science Tyumen Cardiology Scientific Center, Tomsk, Registration number in the EGISU system: 122020300112-4, Code (cipher) assigned by the founder: FGWM-20220024)., исследование проведено в рамках государственного задания Министерства образования и науки РФ (исполнитель – Тюменский кардиологический научный центр, Томский национальный исследовательский медицинский центр Российской академии наук, Томск, Регистрационный номер в системе ЕГИСУ: 122020300112-4, Код (шифр), присвоенный учредителем: FGWM-2022-0024).
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: TSU publishing 2024
• Subjects: факторы риска; Far North; coronary angiography; coronary atherosclerosis; risk factors; Крайний Север; коронароангиография; коронарный атеросклероз; Circumpolar Health; nenets; Nenets Autonomous Okrug; Yamalo Nenets; Yamalo-Nenets Autonomous Okrug; Крайн*
• Online Access: https://www.sibjcem.ru/jour/article/view/2310; https://doi.org/10.29001/1850-9466-2023-606

Aim: To evaluate the features of coronary artery disease (CAD) in patients in the Far North and determination of the potential impact of extreme climatic factors on the development of coronary atherosclerosis. Material and Methods. Using the “Register of performed coronary angiography operations”, 5,679 patients with coronary artery disease were selected, who underwent coronary angiography at the Tyumen Cardiology Research Center. The main study group consisted of 2,590 patients permanently residing in the YamaloNenets Autonomous Okrug and 3,089 patients residing in the South of the Tyumen Region. Results. Patients with permanent residence in the Yamalo-Nenets Autonomous Okrug were on average younger (53.20 ± 7.49 versus 56.79 ± 8.34 years, p < 0.001), men were more common among them. In the extreme North there were more smokers (40.7 vs. 32.0%, p < 0.001) and alcohol users (19.7 vs.15.0%, p < 0.001), and more frequent myocardial infarction in anamnesis (57.1 vs. 48.2%, p < 0.001). At the same time, in patients permanently residing in the South of the Tyumen Region, a burdened hereditary history of CAD was more often determined, and the frequency of arterial hypertension and dyslipidemia was higher. In groups balanced by baseline clinical and demographic characteristics, including CAD risk factors, patients from the Yamal-Nenets Autonomous Okrug had more frequent lesions of the three main coronary arteries: anterior descending artery (42 vs. 35%, p < 0.001), circumflex artery (25 vs. 23%, p = 0.038) and right coronary artery (42 vs. 38%, p = 0.007). It should be noted that in balanced groups in patients permanently residing in the Far North, occlusive lesions of the coronary arteries were statistically significantly more likely to be determined (54 vs. 47%, p < 0.001). Also, between the compared groups, statistically significant differences were found in the type of left ventricle (LV) myocardial remodeling, but these differences were not determined in the balanced groups. Also, in the group of ...