Importance of BRCA1 Y 2 gene mutations in breast cancer
The objective of this research is to provide an updated review of the most important concepts of gene mutations, BRCA1 breast cancer gene 1 or BRCA2, breast cancer gene 2, however, since there is a close correlation with ovarian cancer Given by these mutations, we will also address general informati...
| Published in: | Journal of America health |
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| Main Authors: | , |
| Format: | Article in Journal/Newspaper |
| Language: | Spanish |
| Published: |
Grupo de Salud pública y educación
2021
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| Subjects: | |
| Online Access: | http://jah-journal.com/index.php/jah/article/view/61 https://doi.org/10.37958/jah.v4i1.61 |
| Summary: | The objective of this research is to provide an updated review of the most important concepts of gene mutations, BRCA1 breast cancer gene 1 or BRCA2, breast cancer gene 2, however, since there is a close correlation with ovarian cancer Given by these mutations, we will also address general information about ovarian cancer and provide the tools and diagnostic keys for the timely identification of the pathology. A systematic search of recent research was carried out in Elsevier, Pubmed and Scopus databases of articles published between 2016 and 2020, in English and Spanish. Clinical trials, meta-analyzes, case reports, and data analysis studies were excluded. BRCA1s are associated with more aggressive types with a poorer prognosis of cancer, for this reason breast cancers diagnosed at an early age are indicated for genetic testing, and BRCA2s seem to have a less hereditary relationship, although they develop it at a later age However, the prevalence of BRCA1 and BRCA2 mutations varies according to the country and ethnic group, Ashkenazi Jews, of European origin and countries such as Iceland, Canada, Poland and the Netherlands that have been amplifying in the generations, contributing to this the geographic isolation of the population. El objetivo de esta investigación es proporcionar una revisión actualizada de los conceptos más importantes de las mutaciones de los genes, BRCA1 gen del cáncer de mama 1 o BRCA2, gen del cáncer de mama 2 sin embargo, al existir una estrecha correlación con cáncer de ovarios dadas por estas mutaciones también abordaremos información general del cáncer de ovarios y proporcionar las herramientas y claves diagnósticas para la identificación oportuna de la patología. Se realizó una búsqueda sistemática de investigaciones recientes en bases de datos de Elsevier, Pubmed y Scopus de artículos publicados entre el 2016 al 2020, en el idioma inglés y español. Se excluyeron ensayos clínicos, metaanálisis, reportes de casos y estudios de análisis de datos. Los BRCA1 se asocian con tipos más ... |
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