Vitamin D levels in women with polycystic ovary syndrome: a population-based study

Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Bi...

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Bibliographic Details
Published in:Nutrients
Main Authors: Lumme, J, Sebert, S, Pesonen, P, Piltonen, T, Jarvelin, M-R, Herzig, K-H, Auvinen, J, Ojaniemi, M, Niinimaki, M
Other Authors: UNIVERSITY OF OULU
Format: Article in Journal/Newspaper
Language:English
Published: MDPI AG 2019
Subjects:
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
vitamin D
25(OH)D
polycystic ovary syndrome
population-based study
community setting
body mass index
OLIGOMENORRHEA AND/OR HIRSUTISM
SELF-REPORTED SYMPTOMS
NORTHERN FINLAND
D DEFICIENCY
D SUPPLEMENTATION
PREVALENCE
PREDICTORS
OBESITY
POLYMORPHISMS
REPRODUCTION
Adult
Biomarkers
Case-Control Studies
Female
Finland
Humans
Prospective Studies
Risk Factors
Up-Regulation
0908 Food Sciences
1111 Nutrition and Dietetics
Northern Finland
Online Access:http://hdl.handle.net/10044/1/85500
https://doi.org/10.3390/nu11112831
Description
Summary:Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders. Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, p = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels. Conclusion: In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements.

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