Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample
Background There is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders. Methods We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in ind...
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ftimperialcol:oai:spiral.imperial.ac.uk:10044/1/42451 2023-05-15T17:42:51+02:00 Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample Ramsay, H Barnett, JH Miettunen, J Mukkala, S Maeki, P Liuhanen, J Murray, GK Jarvelin, M-R Ollila, H Paunio, T Veijola, J 2015-04-16 http://hdl.handle.net/10044/1/42451 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358147500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1371/journal.pone.0127602 English eng Public Library of Science PLOS ONE © 2015 Ramsay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics WORKING-MEMORY ABILITY TRAUMATIC BRAIN-INJURY NEUROCOGNITIVE DEFICITS C957T POLYMORPHISM PREFRONTAL CORTEX ALZHEIMER-TYPE YOUNG-PEOPLE OULU BRAIN SCHIZOPHRENIA ATTENTION Adult Alleles Case-Control Studies Cognition Female Finland Genotype Humans Male Polymorphism Single Nucleotide Psychomotor Performance Psychotic Disorders Receptors Dopamine D2 Risk Factors Young Adult General Science & Technology MD Multidisciplinary Journal Article 2015 ftimperialcol https://doi.org/10.1371/journal.pone.0127602 2018-09-16T05:57:36Z Background There is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders. Methods We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. The subjects of the Oulu Brain and Mind Study were drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986). Using linear regression, we compared the associations between cognitive performance and two candidate DRD2 polymorphisms (rs6277 and rs1800497) between subjects having familial (n=61) and clinical (n=45) risk for psychosis and a random sample of participating NFBC 1986 controls (n=74). Cognitive performance was evaluated using a comprehensive battery of tests at follow-up. Results Principal components factor analysis supported a three-factor model for cognitive measures. The minor allele of rs6277 was associated with poorer performance on a verbal factor (p=0.003) but this did not significantly interact with familial or clinical risk for psychosis. The minor allele of rs1800497 was associated with poorer performance on a psychomotor factor (p=0.038), though only in those at familial risk for psychotic disorders (interaction p=0.049). Conclusion The effect of two DRD2 SNPs on cognitive performance may differ according to risk type for psychosis, suggesting that cognitive intermediate phenotypes differ according to the type (familial or clinical) risk for psychosis. Article in Journal/Newspaper Northern Finland Imperial College London: Spiral PLOS ONE 10 6 e0127602 |
institution |
Open Polar |
collection |
Imperial College London: Spiral |
op_collection_id |
ftimperialcol |
language |
English |
topic |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics WORKING-MEMORY ABILITY TRAUMATIC BRAIN-INJURY NEUROCOGNITIVE DEFICITS C957T POLYMORPHISM PREFRONTAL CORTEX ALZHEIMER-TYPE YOUNG-PEOPLE OULU BRAIN SCHIZOPHRENIA ATTENTION Adult Alleles Case-Control Studies Cognition Female Finland Genotype Humans Male Polymorphism Single Nucleotide Psychomotor Performance Psychotic Disorders Receptors Dopamine D2 Risk Factors Young Adult General Science & Technology MD Multidisciplinary |
spellingShingle |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics WORKING-MEMORY ABILITY TRAUMATIC BRAIN-INJURY NEUROCOGNITIVE DEFICITS C957T POLYMORPHISM PREFRONTAL CORTEX ALZHEIMER-TYPE YOUNG-PEOPLE OULU BRAIN SCHIZOPHRENIA ATTENTION Adult Alleles Case-Control Studies Cognition Female Finland Genotype Humans Male Polymorphism Single Nucleotide Psychomotor Performance Psychotic Disorders Receptors Dopamine D2 Risk Factors Young Adult General Science & Technology MD Multidisciplinary Ramsay, H Barnett, JH Miettunen, J Mukkala, S Maeki, P Liuhanen, J Murray, GK Jarvelin, M-R Ollila, H Paunio, T Veijola, J Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample |
topic_facet |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics WORKING-MEMORY ABILITY TRAUMATIC BRAIN-INJURY NEUROCOGNITIVE DEFICITS C957T POLYMORPHISM PREFRONTAL CORTEX ALZHEIMER-TYPE YOUNG-PEOPLE OULU BRAIN SCHIZOPHRENIA ATTENTION Adult Alleles Case-Control Studies Cognition Female Finland Genotype Humans Male Polymorphism Single Nucleotide Psychomotor Performance Psychotic Disorders Receptors Dopamine D2 Risk Factors Young Adult General Science & Technology MD Multidisciplinary |
description |
Background There is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders. Methods We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. The subjects of the Oulu Brain and Mind Study were drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986). Using linear regression, we compared the associations between cognitive performance and two candidate DRD2 polymorphisms (rs6277 and rs1800497) between subjects having familial (n=61) and clinical (n=45) risk for psychosis and a random sample of participating NFBC 1986 controls (n=74). Cognitive performance was evaluated using a comprehensive battery of tests at follow-up. Results Principal components factor analysis supported a three-factor model for cognitive measures. The minor allele of rs6277 was associated with poorer performance on a verbal factor (p=0.003) but this did not significantly interact with familial or clinical risk for psychosis. The minor allele of rs1800497 was associated with poorer performance on a psychomotor factor (p=0.038), though only in those at familial risk for psychotic disorders (interaction p=0.049). Conclusion The effect of two DRD2 SNPs on cognitive performance may differ according to risk type for psychosis, suggesting that cognitive intermediate phenotypes differ according to the type (familial or clinical) risk for psychosis. |
format |
Article in Journal/Newspaper |
author |
Ramsay, H Barnett, JH Miettunen, J Mukkala, S Maeki, P Liuhanen, J Murray, GK Jarvelin, M-R Ollila, H Paunio, T Veijola, J |
author_facet |
Ramsay, H Barnett, JH Miettunen, J Mukkala, S Maeki, P Liuhanen, J Murray, GK Jarvelin, M-R Ollila, H Paunio, T Veijola, J |
author_sort |
Ramsay, H |
title |
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample |
title_short |
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample |
title_full |
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample |
title_fullStr |
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample |
title_full_unstemmed |
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample |
title_sort |
association between dopamine receptor d2 (drd2) variations rs6277 and rs1800497 and cognitive performance according to risk type for psychosis: a nested case control study in a finnish population sample |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
http://hdl.handle.net/10044/1/42451 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358147500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 https://doi.org/10.1371/journal.pone.0127602 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
PLOS ONE |
op_rights |
© 2015 Ramsay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0127602 |
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PLOS ONE |
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10 |
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6 |
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e0127602 |
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1766144779952848896 |