Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample

Background There is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders. Methods We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in ind...

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Bibliographic Details
Published in:PLOS ONE
Main Authors: Ramsay, H, Barnett, JH, Miettunen, J, Mukkala, S, Maeki, P, Liuhanen, J, Murray, GK, Jarvelin, M-R, Ollila, H, Paunio, T, Veijola, J
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science 2015
Subjects:
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
WORKING-MEMORY ABILITY
TRAUMATIC BRAIN-INJURY
NEUROCOGNITIVE DEFICITS
C957T POLYMORPHISM
PREFRONTAL CORTEX
ALZHEIMER-TYPE
YOUNG-PEOPLE
OULU BRAIN
SCHIZOPHRENIA
ATTENTION
Adult
Alleles
Case-Control Studies
Cognition
Female
Finland
Genotype
Humans
Male
Polymorphism
Single Nucleotide
Psychomotor Performance
Psychotic Disorders
Receptors
Dopamine D2
Risk Factors
Young Adult
General Science & Technology
MD Multidisciplinary
Northern Finland
Online Access:http://hdl.handle.net/10044/1/42451
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000358147500009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
https://doi.org/10.1371/journal.pone.0127602
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Summary:Background There is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders. Methods We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. The subjects of the Oulu Brain and Mind Study were drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986). Using linear regression, we compared the associations between cognitive performance and two candidate DRD2 polymorphisms (rs6277 and rs1800497) between subjects having familial (n=61) and clinical (n=45) risk for psychosis and a random sample of participating NFBC 1986 controls (n=74). Cognitive performance was evaluated using a comprehensive battery of tests at follow-up. Results Principal components factor analysis supported a three-factor model for cognitive measures. The minor allele of rs6277 was associated with poorer performance on a verbal factor (p=0.003) but this did not significantly interact with familial or clinical risk for psychosis. The minor allele of rs1800497 was associated with poorer performance on a psychomotor factor (p=0.038), though only in those at familial risk for psychotic disorders (interaction p=0.049). Conclusion The effect of two DRD2 SNPs on cognitive performance may differ according to risk type for psychosis, suggesting that cognitive intermediate phenotypes differ according to the type (familial or clinical) risk for psychosis.

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