Translational implications of bradyarrhythmia in hibernating brown bears

The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state...

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Bibliographic Details
Published in:Physiological Reports
Main Authors: Gottlieb, Lisa Amalie, Evans, Alina, Fuchs, Boris, Fröbert, Ole, Björkenheim, Anna
Format: Article in Journal/Newspaper
Language:English
Published: 2023
Subjects:
bradyarrhythmia
brown bear
hibernation
sinus arrest
sinus node disease
sinus pause
syncope
translational model
Ursus arctos
VDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480
Online Access:https://hdl.handle.net/11250/3119444
https://doi.org/10.14814/phy2.15550
Description
Summary:The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction. publishedVersion

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