Usporedna procjena dvaju gelova s hijaluronskom kiselinom za liječenje interdentalnih papilarnih defekata

• Published in: Acta Stomatologica Croatica
• Main Authors: Mandel, Iván, Farkasdi, Sándor, Varga, Gábor, Nagy, Ákos Károly
• Format: Article in Journal/Newspaper
• Language: English; Croatian
• Published: School of Dental Medicine, University of Zagreb, Croatian Dental Society - Croatian Medical Association 2020
• Subjects: povlačenje gingive; interdentalna papila; hijaluronska kiselina; Gingival Recession; Interdental Papilla; Hyaluronic Acid; Nordland
• Online Access: https://hrcak.srce.hr/243985; https://hrcak.srce.hr/file/354608; https://hrcak.srce.hr/file/354607

Ciljevi: Željela se istražiti učinkovitost pojedinačnih injekcija dvaju različitih proizvoda s hijaluronskom kiselinom –Flex Barriera i Revidenta, u smanjenju veličine crnih trokutatijekom liječenja recesija poput Nordland-Tarnowe klase I i II. Materijali i metode: Četrdeset odraslih pacijenata odabrano je s najmanje dvama gornjim i dvama donjim interdentalnim oštećenjima papile u frontalnom području među očnjacima. Prema klasifikaciji Nordland-Tarnowovih papilarnih oštećenja u ispitivanje su bile uključene i recesije I. i II. razreda. Pacijenti su na-sumično raspoređeni u eksperimentalne skupine kako bi primili pojedinačne injekcije dvaju različitih proizvoda s hijaluronskom kiselinom –bilo Flex Barrier, bilo Revident. Neobrađene stranice poslužile su kao kontrole. Foto-grafije su snimljene prije tretmana i odmah poslije njega, te ponovno nakon tjedan i mjesec dana. Za određivanje veličine crnih trokutakorišten je softver Image J. Za statističke analize primijenjen je miješani oblik ANOVA anali-ze. Rezultati: Flex Barrier i Revident značajno su smanjili tretirane nedostatke odmah nakon tretmana, a također tjedan dana poslije (p < 0,001). Blagotvorni učinak Revidenta trajao je dulje od onoga Flex Bariera, jer je djelovao i nakon mjesec dana kod pacijenata liječenih Revidentom, ali ne u skupini liječenoj Flex Barrierom. Nadalje, lezije klase I Nordland-Tarnowa općenito su pokazale veće poboljšanje od lezija klase II. Zaključak: U ovom do-kumentiranom konceptu randomiziranog kliničkog ispitivanja pokazali smo kliničku primjenjivost i Flex Barriera i Revidenta, iako su s Revidentom postignuta dugotrajnija poboljšanja u usporedbi s Flex Barrierom. Daljnja ispitivanja potrebna su zbog optimizacije protokola s višestrukim aplikacijama za liječenje gingivnih crnih trokuta. Objectives: The aim was to investigate the efficacy of single injections of two different hyaluronic acid products, Flex Barrier and Revident, in reducing the size of black triangles to treat Nordland-Tarnow Class I and II recessions. Material and Methods:Forty adult patients were recruited with at least two upper and two lower interdental papilla defects in the front region between canine teeth. According to the Nordland-Tarnow classification of papillary defects, both Class I and Class II recessions were included in the investigation. Patients were randomly assigned to experimental groups to receive single injections of two different hyaluronic acid products, either Flex Barrier or Revident. The untreat-ed sites served as controls. Photographs were taken before and immediately after the treatment, and again after one week and one month. To determine the size of the black triangles, Image J software was used. For statistical analysis, a mixed-design ANOVA was applied. Results:Both Flex Barrier and Revident significantly decreased the size of the treated defects immediately after the treatment and also one week later (p<0.001). The beneficial effect of Revident lasted longer than Flex Barrier as it remained significant even after one month in Revident-treated patients, however, not in the Flex Barrier-treated group. Furthermore, Nordland-Tarnow Class I lesions generally showed a greater improve-ment than Class II lesions. Conclusion: In this proof-of-concept, randomized clinical trial we have demonstrated the clinical applicability of both Flex Barrier and Revident, although Revident gave longer-lasting improvements than Flex Barrier. Further trials are needed to optimize multiple-application protocols for treating gingival black triangles.