Classification of Hepatitis B Virus Genotype B into 2 Major Types Based on Characterization of a Novel Subgenotype in Arctic Indigenous Populations

Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2–B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belo...

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Bibliographic Details
Published in:The Journal of Infectious Diseases
Main Authors: Sakamoto, Tomoyuki, Tanaka, Yasuhito, Simonetti, Josephine, Osiowy, Carla, Borresen, Malene L., Koch, Anders, Kurbanov, Fuat, Sugiyama, Masaya, Minuk, Gerald Y., McMahon, Brian J., Joh, Takashi, Mizokami, Masashi
Format: Text
Language:English
Published: Oxford University Press 2007
Subjects:
Major Article
Arctic
Online Access:http://jid.oxfordjournals.org/cgi/content/short/196/10/1487
https://doi.org/10.1086/523111
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Summary:Hepatitis B virus genotype B (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2–B5) have undergone recombination with HBV/C in the core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that the Arctic strains belong to a novel subgenotype (HBV/B6) without the recombination, analogous to what is seen with Bj/B1. Comparison of 50 HBV/B6 carriers from the Arctic versus 50 Bj and 50 Ba age- and sex-matched carriers from Asia revealed that clinical characteristics of HBV/B6 carriers were similar to those of Bj/B1 carriers in Japan. The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2–B5) types.

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