Staphylococcus aureus nasal isolates from healthy individuals cause highly variable host cell responses in vitro: The Tromso Staph and Skin Study

Studies on Staphylococcus aureus populations colonizing the nasal cavity reveal that some bacterial strains are more common, while others are rarely found. This study included five isolates with the most common spa types and five isolates with rare spa types from healthy population. Selected phenoty...

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Bibliographic Details
Published in:Pathogens and Disease
Main Authors: Askarian, Fatemeh, Sangvik, Maria, Hanssen, Anne-Merethe, Snipen, Lars, Sollid, Johanna U.E., Johannessen, Mona
Format: Text
Language:English
Published: Oxford University Press 2014
Subjects:
Research Articles
Tromso
Online Access:http://femspd.oxfordjournals.org/cgi/content/short/70/2/158
https://doi.org/10.1111/2049-632X.12099
Description
Summary:Studies on Staphylococcus aureus populations colonizing the nasal cavity reveal that some bacterial strains are more common, while others are rarely found. This study included five isolates with the most common spa types and five isolates with rare spa types from healthy population. Selected phenotypic traits and genomic content among nasal S. aureus isolates were compared. Besides the rather similar growth rates, our data revealed a high diversity among isolates; that is, in biofilm formation, the ability to attach to and be internalized in keratinocytes as well as ability to induce pro- and anti-inflammatory cytokines. The results showed that S. aureus isolates from healthy hosts are phenotypically diverse and cause highly variable host cell responses. Therefore, generalizing the results from one S. aureus isolate to all is highly questionable.

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