Epstein-Barr virus activation in Raji cells by extracts of preserved food from high risk areas for nasopharyngeal carcinoma

Epstein-Barr virus (EBV) activation of latent infection and traditional life styles, especially food habits, have been strongly associated with an increased risk of nasopharyngeal carcinoma (NPC) in humans. On the basis of anthropological studies in Tunisia, southern China and Greenland, extracts of...

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Bibliographic Details
Published in:Carcinogenesis
Main Authors: Shao, Y.M., Poirier, A., Ohshima, H., Malaveille, C., Zeng, Y., Thé, G.de, Bartsch, H.
Format: Text
Language:English
Published: Oxford University Press 1988
Subjects:
ORIGINAL ARTICLES
Greenland
Mutton
Online Access:http://carcin.oxfordjournals.org/cgi/content/short/9/8/1455
https://doi.org/10.1093/carcin/9.8.1455
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Summary:Epstein-Barr virus (EBV) activation of latent infection and traditional life styles, especially food habits, have been strongly associated with an increased risk of nasopharyngeal carcinoma (NPC) in humans. On the basis of anthropological studies in Tunisia, southern China and Greenland, extracts of representative preserved food items consumed frequently by the high-risk populations for NPC were assayed for the presence of EBV activators in Raji cells. A strong EBV activation activity was observed in aqueous extracts of some Cantonese salted dried fish from China, harissa (a spice mixture) and to a lesser extent qaddid (dry mutton preserved in olive oil) from Tunisia. These new data may support epidemiological evidence for the importance of Cantonese salted and dried fish and other food items in the etiology of NPC.

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