A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?

One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to a(2,3)-sialyllactose is stil...

Full description

Bibliographic Details
Published in:Angewandte Chemie International Edition
Main Authors: Lai, Jimmy CC, Garcia, Jean-Michel, Dyason, Jeffrey C, Boehm, Raphael, Madge, Paul D, Rose, Faith J, Nicholls, John M, Peiris, JS Malik, Haselhorst, Thomas, von Itzstein, Mark
Format: Article in Journal/Newspaper
Language:English
Published: Wiley - V C H Verlag GmbH & Co. KGaA 2012
Subjects:
Chemical sciences
Biologically active molecules
Avian flu
Online Access:http://hdl.handle.net/10072/49328
https://doi.org/10.1002/anie.201108245
Description
Summary:One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to a(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of a(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase). No Full Text

Similar Items