Gorgan (Iran) population HLA genetics and anthropology

• Main Authors: Arnaiz-Villena, A., Juarez, I., Joshghan, H., Lopez-Nares, A., Rey, D., Callado, A., H-Sevilla, A., Rashidi, F., Nikbin, B., Amirzargar, A.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: 2020
• Subjects: QS آناتومی انسان; QTفیزیولوژی; آسیب شناسی QZ; بهداشت عمومی WA; mansi; Mansi
• Online Access: http://eprints.goums.ac.ir/10542/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076597576&doi=10.1016%2fj.humimm.2019.11.009&partnerID=40&md5=23efe4d36be5039934eddea9adc71d49

Gorgan (Iran) have been studied for HLA-A, -B, -C, -DRB1 and -DQB1 genes for the first time. They are Turkmen and originated in East Asia around Altai Mts; they originally spoke a Turk language classified within the Turkish-Oguz group. Peripheral blood samples were collected from Gorgan City (Iran) and HLA typed by standard methodology. HLA allele frequencies were compared with 7984 chromosomes of other World populations and it was shown existence of admixture of Siberian and Mediterranean HLA characters in this population, probably due to longlasting contact with Persians. Three new HLA extended haplotypes were found: A*01:01-B*35:01-DRB1*03:01-DQB1*02:01, A*30:01-B*13:01-DRB1*15:01-DQB1*02:01 and A*31:01-B*35:01-DRB1*15:01-DQB1*03:01. Gorgan (Iran) were most close to Chuvashians (Noth Caspian Sea, Russia) and Siberians, like Tuvinians, Mansi and Buryats in Neighbour Joining and Vista analyses. It is established a relationship of this population with Kurgan (Gorgan, Iran) archaeological mounds culture. However, their kinship with Scythians (2nd century BC) and Sarmatians (4th century AD) is obscure although both of them spoke a Persian language. © 2019 American Society for Histocompatibility and Immunogenetics