Table_2_Maternal Supplementation With Krill Oil During Breastfeeding and Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) Composition of Human Milk: A Feasibility Study.DOCX

• Main Authors: Anna Giulia Cimatti, Silvia Martini, Alessandra Munarini, Maximilano Zioutas, Francesca Vitali, Arianna Aceti, Vilma Mantovani, Giacomo Faldella, Luigi Corvaglia
• Format: Dataset
• Language: unknown
• Published: 2018
• Subjects: Foetal Development and Medicine; Obstetrics and Gynaecology; Paediatrics; Paediatrics and Reproductive Medicine not elsewhere classified; LCPUFA; DHA; AA; EPA; breast milk; supplementation; krill oil; lactation; Antarctic; Antarc*; Antarctic Krill
• Online Access: https://doi.org/10.3389/fped.2018.00407.s002; https://figshare.com/articles/Table_2_Maternal_Supplementation_With_Krill_Oil_During_Breastfeeding_and_Long-Chain_Polyunsaturated_Fatty_Acids_LCPUFAs_Composition_of_Human_Milk_A_Feasibility_Study_DOCX/7497935

Background: Docosahexaenoic acid (DHA) is a major constituent of neuronal and retinal membranes and plays a crucial role in brain and visual development within the first months of life. Dietary intakes are fundamental to provide neonates with adequate DHA supply; hence, maternal supplementation might represent a useful strategy to implement DHA contents in breast milk (BM), with possible benefits on neonatal neurodevelopment. Antarctic krill is a small crustacean rich in highly available phospholipid-bound DHA. This pilot study aimed to evaluate whether maternal supplementation with krill oil during breastfeeding increases long-chain polyunsaturated fatty acids (LCPUFAs) BM contents. Methods: Mothers of infants admitted to the Neonatal Intensive Care Unit were enrolled in this open, randomized-controlled study between 4 and 6 weeks after delivery and randomly allocated in 2 groups. Group 1 received an oral krill oil-based supplement providing 250 mg/day of DHA and 70 mg/day of eicosapentaenoic acid (EPA) for 30 days; group 2 served as control. BM samples from both groups were collected at baseline (T0) and day 30 (T1) and underwent a qualitative analysis of LCPUFAs composition by gas chromatography/mass spectrometry. Results: Sixteen breastfeeding women were included. Of these, 8 received krill-oil supplementation and 8 were randomized to the control group. Baseline percentage values of DHA (%DHA), arachidonic acid (ª), and EPA (%EPA) did not differ between groups. A significant increase in %DHA (T0: median 0.23% [IQR 0.19;0.38], T1:0.42% [0.32;0.49], p 0.012) and %EPA (T0: median 0.10% [IQR 0.04;0.11], T1:0.11% [0.04;0.15], p 0.036) and a significant reduction in ª (T0: median 0.48% [IQR 0.42;0.75], T1:0.43% [0.38;0.61], p 0.017) between T0 and T1 occurred in Group 1, whereas no difference was seen in Group 2. Consistently, a significant between-group difference was observed in percentage changes from baseline of DHA (Δ%DHA, group 1: median 64.2% [IQR 27.5;134.6], group 2: −7.8% [−12.1;−3.13], p 0.025) and EPA ...