Table_2_Dysregulation of microRNAs may contribute to neurosensory impairment in Arctic cod (Boreogadus saida) following CO2 exposure.xlsx

MicroRNAs (miRNAs) are epigenetic markers with a key role in post-transcriptional gene regulation. Several studies have described the dysregulation of miRNAs in temperature and hypoxic stress responses of marine organisms, but their role in the response to acidification conditions has remained relat...

Full description

Bibliographic Details
Main Authors: Cara C. Schweitzer, Carolina A. Bonin, Christopher Magel, Thomas P. Hurst, Andrij Z. Horodysky
Format: Dataset
Language:unknown
Published: 2023
Subjects:
Oceanography
Marine Biology
Marine Geoscience
Biological Oceanography
Chemical Oceanography
Physical Oceanography
Marine Engineering
microRNA
ocean acidification
environmental stressors
climate change
hearing loss
fish
neurosensory
Arctic cod
Arctic
Boreogadus saida
Climate change
Ocean acidification
Online Access:https://doi.org/10.3389/fmars.2023.1247344.s002
https://figshare.com/articles/dataset/Table_2_Dysregulation_of_microRNAs_may_contribute_to_neurosensory_impairment_in_Arctic_cod_Boreogadus_saida_following_CO2_exposure_xlsx/24248503
Description
Summary:MicroRNAs (miRNAs) are epigenetic markers with a key role in post-transcriptional gene regulation. Several studies have described the dysregulation of miRNAs in temperature and hypoxic stress responses of marine organisms, but their role in the response to acidification conditions has remained relatively underexplored. We investigated the differential expression of miRNAs in whole brain tissue of Arctic cod (Boregogadus saida) exposed to elevated aqueous CO 2 levels representative of future climate change predictions. We detected the expression of 17 miRNAs of interest that are either directly or indirectly associated with reduced auditory performance; 12 of the 17 miRNAs showed significant differential expression in high treatment vs. low (control) aqueous CO 2 conditions. Target gene predictions indicated that these miRNAs are likely involved with inner ear maintenance, hair cell degradation, age-related hearing loss, neural inflammation, and injury. The highest differential expression was observed in mir-135b, which is linked with increased neural inflammation and injury that may be associated with neurosensory dysfunction. Collectively, these results elucidate the contributions of miRNA mechanisms underlying CO 2 -induced sensory deficits in fishes facing abiotic environmental change and suggest strong potential for this approach to yield novel insights into the mechanistic effects of climate change on marine organisms.

Similar Items