| Summary: | Black rats, Rattus rattus (L.) (Rodentia: Muridae) (R. rattus), belong to the rodents that have a major negative impact on the agriculture economy in all aspects. The objective of the research was to determine the effect of a methanolic extract of Lantana camara leaves (L. camara), which was employed as a natural source of plant-derived compounds, on the control procedure against R. rattus. The results indicate that the LD50 and LD90 values for lantana extract were 894.43 and 2948.96 mg/kg body weight, respectively. Significant decrease in the test animals' body weight. As a biological response indicator, there is a significant increase in some biological parameters such as alnine transaminase (ALT), aspartate transaminase (AST), serum urea, creatinine, and lactate dehydrogenase (LDH). The liver, kidney, and heart sections had histopathological changes, including degeneration and necrosis in many hepatic regions with pyknotic nuclei. Certain convoluted tubules have vacuolar degeneration, and the proximal and distal convoluted tubules' structures are disorganized. The cardiac muscle fibers are widely spaced from each other and have certain necrotic areas. The methanol leaves extract included 11 compounds, according to GC/MS analysis. Field evaluation by employing bait consumption resulted in an acceptable reduction of 65.36% for lantana extract and an 84.72% reduction for the commercially rodenticide zinc phosphide.
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