How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish

Despite the use of fish models to study human mental disorders and dysfunctions, knowledge of regional telencephalic responses in non-mammalian vertebrates expressing alternate stress coping styles is poor. Since perception of salient stimuli associated with stress coping in mammals is mainly under...

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Bibliographic Details
Published in:Journal of Experimental Biology
Main Authors: Vindas, Marco A, Gorissen, Marnix, Höglund, Erik, Flik, Gert, Tronci, Valentina, Damsgård, Børge, Thörnqvist, Per-Ove, Nilsen, Tom O., Winberg, Svante, Øverli, Øyvind, Ebbesson, Lars O. E.
Format: Article in Journal/Newspaper
Language:English
Published: 2017
Subjects:
Atlantic salmon
BDNF
limbic areas
neural plasticity
serotonin
Online Access:https://orbit.dtu.dk/en/publications/6fa95102-f82b-4a52-8e6e-88578d8cdca2
https://doi.org/10.1242/jeb.153213
https://backend.orbit.dtu.dk/ws/files/139260757/Publishers_version.pdf
http://jeb.biologists.org/content/early/2017/02/02/jeb.153213
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Summary:Despite the use of fish models to study human mental disorders and dysfunctions, knowledge of regional telencephalic responses in non-mammalian vertebrates expressing alternate stress coping styles is poor. Since perception of salient stimuli associated with stress coping in mammals is mainly under forebrain limbic control, we tested region-specific forebrain neural (i.e mRNA abundance and monoamine neurochemistry) and endocrine responses at basal and acute stress conditions for previously characterised proactive and reactive Atlantic salmon. Reactive fish show a higher degree of the neurogenesis marker proliferating cell nuclear antigen (pcna) and dopamine activity under basal conditions in Dl (proposed hippocampus homologue) and higher post-stress plasma cortisol levels. Proactive fish displayed post-stress higher serotonergic signalling (i.e. higher serotonergic activity and expression of the 5-HT1A receptor abundance) in the proposed amygdala homologue (Dm), increased expression of the neuroplasticity marker brain derived neurotropic factor (bdnf) in both Dl and Vv (lateral septum homologue), as well as increased expression of the corticotropin releasing factor 1 (crf1) receptor in the Dl, in line with active coping neuro-profiles reported in the mammalian literature. We present novel evidence of proposed functional equivalences in the fish forebrain with mammalian limbic structures.

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