Molecular epidemiological study of Arctic rabies virus isolates from Greenland and comparison with isolates from throughout the Arctic and Baltic regions

We report a Molecular epidemiological study of rabies in Arctic Countries by comparing a panel of novel Greenland isolates to a larger cohort of viral sequences from both Arctic and Baltic regions. Rabies Virus isolates originating from wildlife (Arctic/red foxes, raccoon-dogs and reindeer), from do...

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Bibliographic Details
Published in:Virus Research
Main Authors: Mansfield, K.L., Racloz, V., McElhinney, L.M., Marston, D.A., Johnson, N., Rønsholt, L., Christensen, Laurids Siig, Neuvonen, E., Botvinicin, A.D., Rupprecht, C.E., Fooks, A.R.
Format: Article in Journal/Newspaper
Language:English
Published: 2006
Subjects:
Greenland
fox
Baltic
zoonosis
wildlife
rabics
Arctic
Canada
Yakutia
Alaska
Siberia
Online Access:https://orbit.dtu.dk/en/publications/2f74d6e8-8b2a-488e-a292-747ee2ef0e80
https://doi.org/10.1016/j.virusres.2005.08.007
Description
Summary:We report a Molecular epidemiological study of rabies in Arctic Countries by comparing a panel of novel Greenland isolates to a larger cohort of viral sequences from both Arctic and Baltic regions. Rabies Virus isolates originating from wildlife (Arctic/red foxes, raccoon-dogs and reindeer), from domestic animals (dogs/cats) and from two human cases were investigated. The resulting 400 bp N-gene sequences were compared with isolates representing neighbouring Arctic or Baltic Countries from North America, the former Soviet Union and Europe. Phylogenetic analysis demonstrated similarities between sequences from the Arctic and Arctic-like viruses, which were distinct from rabies isolates originating ill the Baltic region of Europe, the Steppes in Russia and from North America. The Arctic-like group consist of isolates from India, Pakistan, southeast Siberia and Japan. The Arctic group Was differentiated into two lineages, Arctic 1 and Arctic 2, with good bootstrap Support. Arctic I is mainly comprised of Canadian isolates with a single fox isolate front Maine in the USA. Arctic 2 was further divided into sub-lineages: 2a/2b. Arctic 2a comprises isolates from the Arctic regions of Yakutia in northeast Siberia and Alaska. Arctic 2b isolates represent a biotype, which is dispersed throughout the Arctic region. The broad distribution of rabies in the Arctic regions including Greenland, Canada and Alaska provides evidence for the movement of rabies across borders.

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