Evaluating the Effects of Stressors on Immune Function during Simulated Dives in Marine Mammals

The overall goals of this research are to investigate the response of marine mammal immune cells to simulated dives, and to evaluate the effects of stressors on this response. The study will investigate both innate and acquired immune function in both beluga whales and seals in response to challenge...

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Bibliographic Details
Main Authors: Romano, Tracy, Thompson, Laura
Other Authors: MYSTIC AQUARIUM AND INST FOR EXPLORATION CT
Format: Text
Language:English
Published: 2013
Subjects:
Biochemistry
Biology
Stress Physiology
*DIVING
*IMMUNOLOGY
*LYMPHOCYTES
*PHYSIOLOGICAL EFFECTS
*RESPONSE(BIOLOGY)
*SEALS(MAMMALS)
*STRESS(PHYSIOLOGY)
*WHALES
BLOOD ANALYSIS
COMPRESSION
COMPUTERIZED SIMULATION
DECOMPRESSION
HORMONES
HUMANS
PRESSURE
RETICULOENDOTHELIAL SYSTEM
UNDERWATER SOUND
*IMMUNE SYSTEM RESPONSE
*IMMUNE CELL RESPONSE
*BELUGA WHALES
*CELLULAR IMMUNE FUNCTION
STRANDED SEALS
RELEASED SEALS
IMMUNE FUNCTION RESPONSE
SIMULATED DIVES
PHAGOCYTOSIS
NEUTROPHIL ACTIVATION
LYMPHOCYTE ACTIVATION
LYMPHOCYTE PROLIFERATION
WILD BELUGA WHALES
AQUARIUM BELUGA WHALES
NEUTROPHIL PHAGOCYTOSIS
NEUTROPHIL EXPRESSION OF CD11B
T CELL EXPRESSION OF IL2 RECEPTOR
COMPARATIVE ANALYSIS
Beluga
Beluga*
Online Access:http://www.dtic.mil/docs/citations/ADA599702
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA599702
Description
Summary:The overall goals of this research are to investigate the response of marine mammal immune cells to simulated dives, and to evaluate the effects of stressors on this response. The study will investigate both innate and acquired immune function in both beluga whales and seals in response to challenges associated with diving (i.e., pressure), both with and without the presence of an additional stressor. The specific objectives of this effort are as follows: (1) to investigate the effects of simulated dive exposures on cellular immune function in beluga whales, (2) to evaluate the effects of simulated dive exposures on cellular immune function following a known stressor event, (3) to collect biological samples from wild belugas to compare with aquarium whales, and (4) to compare the effects of simulated dive exposures on cellular immune function in seals between stranding (stressor) and release (healthy).

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