Thyroid Alterations in Porcine After Prolonged Exposure to Cold or Heat

• Main Authors: Young, Bruce A., Cosgrove, Sarah J., Christopherson, Robert J.
• Other Authors: NAVAL MEDICAL RESEARCH INST BETHESDA MD
• Format: Text
• Language: English
• Published: 1992
• Subjects: Biology; Medicine and Medical Research; *THYROTROPIN; *THYROXINE; *THYROID HORMONES; LOW TEMPERATURE; NAVAL PERSONNEL; HEAT ACCLIMATIZATION; SWINE; COLD TOLERANCE; MILITARY MEDICINE; HUMANS; PE62233N; WUDN247509; WU1002; Antarctic; Antarc*; Antarctica
• Online Access: http://www.dtic.mil/docs/citations/ADA266840; http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA266840

Studies by the Naval Medical Research Institute on humans after prolonged antarctic residence have shown possible intracellular thyroid hormone alternations. These studies demonstrated a rise in serum clearance of orally administered triiodothyronine (T3), T3 production and T3 total volume distribution in naval personnel after a 42 week residence in Antarctica compared to a control period in California (21). The increased serum clearance and total pool of T3 indicated a possible intracellular response which could not be further investigated using human subjects. An animal model permitted prolonged confinement of subjects in temperature controlled chambers and the use of radioisotopes to label T3.