Thyroid Alterations in Porcine After Prolonged Exposure to Cold or Heat

Studies by the Naval Medical Research Institute on humans after prolonged antarctic residence have shown possible intracellular thyroid hormone alternations. These studies demonstrated a rise in serum clearance of orally administered triiodothyronine (T3), T3 production and T3 total volume distribut...

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Bibliographic Details
Main Authors: Young, Bruce A., Cosgrove, Sarah J., Christopherson, Robert J.
Other Authors: NAVAL MEDICAL RESEARCH INST BETHESDA MD
Format: Text
Language:English
Published: 1992
Subjects:
Biology
Medicine and Medical Research
*THYROTROPIN
*THYROXINE
*THYROID HORMONES
LOW TEMPERATURE
NAVAL PERSONNEL
HEAT ACCLIMATIZATION
SWINE
COLD TOLERANCE
MILITARY MEDICINE
HUMANS
PE62233N
WUDN247509
WU1002
Antarctic
Antarc*
Antarctica
Online Access:http://www.dtic.mil/docs/citations/ADA266840
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA266840
Description
Summary:Studies by the Naval Medical Research Institute on humans after prolonged antarctic residence have shown possible intracellular thyroid hormone alternations. These studies demonstrated a rise in serum clearance of orally administered triiodothyronine (T3), T3 production and T3 total volume distribution in naval personnel after a 42 week residence in Antarctica compared to a control period in California (21). The increased serum clearance and total pool of T3 indicated a possible intracellular response which could not be further investigated using human subjects. An animal model permitted prolonged confinement of subjects in temperature controlled chambers and the use of radioisotopes to label T3.

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