Manual of Hemorrhagic Fever with Renal Syndrome

Studies have confirmed that the epidemic hemorrhagic fever in the people's Republic of China and the Far Eastern hemorrhagic nephroso-nephritis in the Soviet Union are caused by the same virus and the HFRS in European Russian and the Balkan countries and nephropathia epidemica in Scandinavia ar...

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Bibliographic Details
Main Authors: Lee, Ho W., Dalrymple, Joel M.
Other Authors: KOREA UNIV SEOUL INST FOR VIRAL DISEASES
Format: Text
Language:English
Published: 1989
Subjects:
Medicine and Medical Research
*SIGNS AND SYMPTOMS
*HEMORRHAGIC FEVERS
RATS
DISEASES
JAPAN
SURVEYS
DIAGNOSIS(GENERAL)
LUNG
MANUAL OPERATION
PATIENTS
KOREA
VIRUSES
MORTALITY RATE
LOW RATE
SEROLOGY
ANTIGENS
LANDFORMS
YUGOSLAVIA
EPIDEMIOLOGY
EURASIA
CHINA
SWEDEN
URBAN AREAS
EAST(DIRECTION)
FINLAND
KIDNEYS
HEMORRHAGE
FAR EAST
HUNGARY
GROUP B ARBOVIRUSES
KIDNEY DISEASES
HANTAAN VIRUS
NEPHRITIS
USSR
EUROPE
RENAL SYNDROME
Rattus rattus
Online Access:http://www.dtic.mil/docs/citations/ADA229139
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA229139
Description
Summary:Studies have confirmed that the epidemic hemorrhagic fever in the people's Republic of China and the Far Eastern hemorrhagic nephroso-nephritis in the Soviet Union are caused by the same virus and the HFRS in European Russian and the Balkan countries and nephropathia epidemica in Scandinavia are caused by Puumala virus, an antigenically related Bunyavirus that is distinguishable serologically from Hantaan virus. The nephropathia epidemica antigen has been detected and the virus has been isolated from the lungs of the reservoir bank voles (Clethrionomys glareolus). In addition, serologic surveys of patients in Sweden, Finland, Hungary, Yugoslavia, and European Russia have shown that both the Hantaan and Puumala serotypes are circulating in these areas. The availability of Hantaan virus antigen has further permitted the diagnosis of urban cases throughout Korea, China, and Japan of a disease, transmitted to man from urban commensal rats (Ratus norvegicus and Rattus rattus), which is characterized by mild nephropathy with minimal shock or hemorrhagic diathesis or by only flu-like symptoms with albuminuria. Thus, Hantaan and related viruses cause an acute viral nephropathy across much of the Eurasian landmass in the form of a hemorrhagic disease of great clinical severity. Mortality rates range from 5% to more than 20% in East Asia. Lower mortality rates are found in nephropathia epidemica, a much milder form of non-hemorrhagic nephropathy in Scandinavia.

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