World Reference Center for Arboviruses.

Revisions were made of the genera Phlebovirus, Orbivirus, Bunyavirus, and the family Rhabdoviridae. New viruses of the Kemerovo and Sakhalin serogroups were identified. Serological evidence of phlebovirus antibody was found in sera from Greece, and of flavi- alpha- and bunyaviruses in sera from the...

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Bibliographic Details
Main Author: Shope,Robert E
Other Authors: YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
Format: Text
Language:English
Published: 1983
Subjects:
Microbiology
*ARBOVIRUSES
*SEROLOGY
ANTIBODIES
CLONES
DENGUE
DETECTION
GLOBAL
GREECE
HEMORRHAGIC FEVERS
INFECTIOUS DISEASES
JAPANESE ENCEPHALITIS
NEUTRALIZATION
RESPONSE
RIFT VALLEY FEVER
RIFT VALLEY FEVER VIRUS
RIVERS
SANDFLY FEVER VIRUS INFECTION
SUDAN
VIRUSES
YELLOW FEVER
GROUP B ARBOVIRUSES
ARTHROPOD BORNE DISEASES
RIBONUCLEIC ACIDS
TAXONOMY
IMMUNOASSAY
ENZYMES
GEOGRAPHICAL DISTRIBUTION
TECHNICAL INFORMATION CENTERS
Phleboviruses
Orbiviruses
Bunyaviruses
Monoclonal antibodies
ELISA(Enzyme Linked Immunosorbant Assay)
Dengue virus
Rhabdoviruses
PE61102A
ASS10
WU073
Sakhalin
Online Access:http://www.dtic.mil/docs/citations/ADA181440
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA181440
Description
Summary:Revisions were made of the genera Phlebovirus, Orbivirus, Bunyavirus, and the family Rhabdoviridae. New viruses of the Kemerovo and Sakhalin serogroups were identified. Serological evidence of phlebovirus antibody was found in sera from Greece, and of flavi- alpha- and bunyaviruses in sera from the Sudan. Zinga virus was identified as Rift Valley fever virus, extending the range from Senegal to Madagasgar. Rift Valley fever antibody was shown to persist 49 years infection; the antibody was still in high titer. A new technique to conduct hybridization of ssRNA was developed as a modification of the Southern blot. Monoclonal antibody to Rift Valley fever virus established that there are at least 6 surface-reactive sites, 4 of these involved in the neutralization reaction. The ELISA was used effectively to screen Rift Valley fever vaccinees for antiboby. Both the IgM and IgC ELISA were developed for Rift Valley fever. The ELISA was also adapted to Crimean-Congo hemorrhagic fever virus for antibody detection. Fifty-two new acquisitions, including Japanese encephalitis, dengue yellow fever, phlebotomus fever viruses, and Ross River, were lyophilized and are available for investigators on request. Keywords: Viruses; Hemorrhagic fever viruses.

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