Study of Nephropathia Epidemica in Sweden.

Nephropathia epidemica (NE) is a significant cause of human morbidity in Norway, Sweden and Finland. The disease is a member of the Hemorrhagic Fever with Renal Syndrome (HFRS) complex. An epidemiological study of human NE cases has shown the endemic area to be north of the 60th parallel. This zone...

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Bibliographic Details
Main Author: Niklasson,Bo
Other Authors: NATIONAL BACTERIOLOGICAL LAB STOCKHOLM (SWEDEN)
Format: Text
Language:English
Published: 1985
Subjects:
Medicine and Medical Research
*HEMORRHAGIC FEVERS
*EPIDEMIOLOGY
HUMANS
POPULATION
ANTIBODIES
INFECTIOUS DISEASES
RODENTS
NORWAY
VIRUS DISEASES
SWEDEN
ISLANDS
HOSTS(BIOLOGY)
FINLAND
KIDNEYS
MORBIDITY
ARBOVIRUSES
Bunyaviruses
Bunyaviridae
Korean Hemorrhagic fever
Nephropathia Epidemica
PE61102A
ASS10
WU542
Norway
Fennoscandia
Online Access:http://www.dtic.mil/docs/citations/ADA161747
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA161747
Description
Summary:Nephropathia epidemica (NE) is a significant cause of human morbidity in Norway, Sweden and Finland. The disease is a member of the Hemorrhagic Fever with Renal Syndrome (HFRS) complex. An epidemiological study of human NE cases has shown the endemic area to be north of the 60th parallel. This zone also correspond with the Fennoscandia biotype. The bank vole, Clethrionomys glareolus, the host of NE virus, is widely distributed in Sweden except for the island Gotland where it is absent. NE infected voles could only be found in endemic areas. Antibody prevalence in human populations from different parts of Sweden was evaluated by IFT using Korean hemorrhagic fever (KHF) infected A-549 cells. Antibody prevalence varied between 2.5-25% in endemic area and was 1% in one non-endemic area. Gotland (the vole free island) had no antibody positive humans. The NE agent, a Bunyavirus, has been isolated from infected voles trapped in the endemic area. The virus has been adapted to Vero E6 cells. The earlier described partial one way cross between NE and KHF has been confirmed. A Clethrionomys glareolus colony originating from an non-endemic area has been established and proven to be susceptible to NE infection. In a pilot study, wild trapped Clethrionomys from an endemic area have shown a lower susceptibility to NE infection compared to the colony animals. This experiment is being repeated under controlled conditions.

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