LABORATORY INVESTIGATION OF ARCTIC STRAINS OF RABIES VIRUS

• Main Author: Crandell,Robert A.
• Other Authors: USAF EPIDEMIOLOGICAL LAB LACKLAND AFB TEX
• Format: Text
• Language: English
• Published: 1964
• Subjects: *RABIES VIRUS; DIAGNOSIS(MEDICINE); IDENTIFICATION; ANTIGENS; ANTIBODIES; FLUORESCENCE; MORPHOLOGY(BIOLOGY); IMMUNE SERUMS; HISTOLOGICAL TECHNIQUES; BIOLOGICAL STAINS; TISSUES(BIOLOGY); BRAIN; CYTOPLASM; NERVE CELLS; MICE; GUINEA PIGS; HAMSTERS; RABBITS; Arctic; Greenland
• Online Access: http://www.dtic.mil/docs/citations/AD0621332; http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=AD0621332

Viruses identified as rabies by the demonstration of negri bodies in experimental animals, immunofluorescence technic, and serum-virus neutralization tests were isolated from animals from Greenland. In comparing several laboratory diagnostic methods for detection of the virus, the fluorescent antibody technic and mouse inoculation method were shown to be equally sensitive. Rabbits, guinea pigs, white mice, and hamsters were susceptible to infection by different routes of inoculation. Hamsters were found to be more susceptible than white mice for primary isolation. Rabbits were more refractory than the other species studied. In addition to various types of cytoplasmic inclusion bodies, intranuclear inclusions were demonstrated in nerve cells of some brains of laboratory-infected animals. (Author) Pub. in Acta path et microbiol scandinav v63 p587-96 1965 (Copies available only to DDC users).