LABORATORY INVESTIGATION OF ARCTIC STRAINS OF RABIES VIRUS

Viruses identified as rabies by the demonstration of negri bodies in experimental animals, immunofluorescence technic, and serum-virus neutralization tests were isolated from animals from Greenland. In comparing several laboratory diagnostic methods for detection of the virus, the fluorescent antibo...

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Bibliographic Details
Main Author: Crandell,Robert A.
Other Authors: USAF EPIDEMIOLOGICAL LAB LACKLAND AFB TEX
Format: Text
Language:English
Published: 1964
Subjects:
*RABIES VIRUS
DIAGNOSIS(MEDICINE)
IDENTIFICATION
ANTIGENS
ANTIBODIES
FLUORESCENCE
MORPHOLOGY(BIOLOGY)
IMMUNE SERUMS
HISTOLOGICAL TECHNIQUES
BIOLOGICAL STAINS
TISSUES(BIOLOGY)
BRAIN
CYTOPLASM
NERVE CELLS
MICE
GUINEA PIGS
HAMSTERS
RABBITS
Arctic
Greenland
Online Access:http://www.dtic.mil/docs/citations/AD0621332
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=AD0621332
Description
Summary:Viruses identified as rabies by the demonstration of negri bodies in experimental animals, immunofluorescence technic, and serum-virus neutralization tests were isolated from animals from Greenland. In comparing several laboratory diagnostic methods for detection of the virus, the fluorescent antibody technic and mouse inoculation method were shown to be equally sensitive. Rabbits, guinea pigs, white mice, and hamsters were susceptible to infection by different routes of inoculation. Hamsters were found to be more susceptible than white mice for primary isolation. Rabbits were more refractory than the other species studied. In addition to various types of cytoplasmic inclusion bodies, intranuclear inclusions were demonstrated in nerve cells of some brains of laboratory-infected animals. (Author) Pub. in Acta path et microbiol scandinav v63 p587-96 1965 (Copies available only to DDC users).

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