Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis

• Published in: Neuropsychiatric Disease and Treatment
• Main Authors: Hestad,Knut A, Engedal,Knut, Whist,Jon Elling, Aukrust,PÃ¥l, Farup,Per G, Mollnes,Tom Eirik, Ueland,Thor
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Press 2016
• Subjects: Neuropsychiatric Disease and Treatment; Bodø; Engedal; Hestad; Jebsen; Mollnes; Pål; Tromsø; Tønsberg; Vestfold; Nordland; University of Tromsø
• Online Access: https://www.dovepress.com/patients-with-depression-display-cytokine-levels-in-serum-and-cerebros-peer-reviewed-fulltext-article-NDT

Knut A Hestad,1–3 Knut Engedal,4 Jon Elling Whist,1 Pål Aukrust,5–9 Per G Farup,1,10 Tom Eirik Mollnes,9,11–13 Thor Ueland5,7,91Department of Research, Innlandet Hospital Trust, Brumunddal, 2Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology (NTNU), Trondheim, 3Department of Public Health, Hedmark University College, Elverum, 4Norwegian Centre for Aging and Health, Vestfold Health Trust, Tønsberg, 5Research Institute of Internal Medicine, 6Section of Clinical Immunology and Infectious Diseases, 7Institute of Clinical Medicine, Oslo University Hospital Rikshospitalet, 8K.G. Jebsen IRC, University of Oslo, Oslo, 9K.G. Jebsen TREC, University of Tromsø, Tromsø, 10Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, 11Centre of Molecular Inflammation Research, Norwegian University of Science and Technology (NTNU), Trondheim, 12Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, 13Research Laboratory, Nordland Hospital, Bodø, NorwayIntroduction: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as a major symptom, but no change in emotional state.Methods: The diagnoses of the patients with depression were according to the International Classification of Diseases, tenth edition (F32–34 spectra). Cytokine profiles in serum and CSF were determined by multiplex analysis, including 27 cytokines, chemokines, and growth factors.Results: No differences could be found between the two groups studied regarding cytokine levels in serum or CSF except for serum interleukin (IL)-1 receptor ...