Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil Exposição de produtos do sangue, acelulares e o risco da infecção pelo VIH, em hemofílicos de Belo Horizonte, Brasil

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Fernando A. Proietti, Anna Barbara F. C. Proietti, Maria Fernanda F. L. Costa, Carlos M. F. Antunes, Mark D. C. Guimarães, Urquiza H. M. Paulino, Caio J. C. Souza, Laércio Melo, Álvaro Munõz
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1992
• Subjects: Hemophiliacs; HIV; blood products; Brazil; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Entrada
• Online Access: https://doi.org/10.1590/S0036-46651992000300008; https://doaj.org/article/fc5906a475ec49f7ac08411efb8ec45c

Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from São Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused Resultados de um estudo da prevalência de infecção pelo VIH, realizado em hemofílicos em Belo Horizonte são apresentados. História prévia de exposição a componentes acelulares do sangue foi determinada para o período de 5 anos anteriores à entrada no estudo, que transcorreu durante 1986 e 1987. Pacientes com distúrbios da coagulação (hemofilia A n = 132, hemofilia B n = 16 e outros distúrbios da coagulação que não hemofilia n = 16), foram transfundidos com crio-precipitado líquido, localmente produzido, crio-precipitado liofilizado, importado de São Paulo, e Fator VIII e IX, importado do Rio de Janeiro, Europa e Estados Unidos. Trinta e seis (22%) resultaram soropositivos para o VIH. A análise univariada e multivariada (regressão logística) ...