Staphylococcus aureus con resistencia múltiple a los antibióticos (MDR) en un Hospital de Maracaibo-Venezuela

• Main Authors: Gómez-Gamboa Liliana, Núñez-Chacín Daniela, Perozo-Mena Armindo, Bermúdez-González José, Marín Milagros
• Format: Article in Journal/Newspaper
• Language: English; Spanish
• Published: Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales 2016
• Subjects: Staphylococcus aureus; resistencia a oxacilina; multidrogo-resistencia; gen mecA; Oxacillin-resistant Staphylococcus aureus; multidrug-resistance; mecA gene; antibiotypes; Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Baja; Cadena
• Online Access: https://doaj.org/article/fa4939aeb5874f6e9f74c46193b0358b

Abstract: Oxacillin-resistant Staphylococcus aureus (ORSA) has remained a major cause of nosocomial infections worldwide. The antibiotic resistance of isolations was determined and we classify them in multidrug-resistant, extensively drug-resistant or pandrug-resistant. The biological samples of patients from a Maracaibo’s Hospital, during September 2013 to February 2014, were processed according to conventional techniques of bacteriology. Antibiotic resistance was determined by disk diffusion method in agar and the mecA gene was detected by polymerase chain reaction. It was observed a low prevalence of nosocomial ORSA (13.86%). The higher antibiotic resistance was observed against erythromycin (66.07%) and a resistance lower than 25% to aminoglycosides, fluoroquinolones, tetracycline and clindamycin. The isolates showed a very low resistance to trimethoprim/sulfamethoxazole and all isolates were susceptible to rifampicin, linezolid, vancomycin and teicoplanin.The majority of isolates had a MSB phenotype (33.93%), with erythromycin resistance and susceptibility to clindamycin. The ORSA isolates in this study had 25 different antibiotypes and the majority of them were multidrug-resistant (55.36%). There was not both extensively drugresistant and pandrug-resistant isolates and the presence of the mecA gene was demonstrated in all isolates of ORSA. Resumen: Staphylococcus aureus resistente a oxacilina (SAOR) continúa siendo una causa importante de infecciones nosocomiales en todo el mundo. Se determinó la resistencia a los antibióticos de cepas intrahospitalarias, clasificándolas en multidrogo-resistentes, extensamente drogo-resistentes o pandrogo-resistentes. Las muestras biológicas fueron recolectadas entre septiembre 2013-febrero 2014 y procesadas de acuerdo a técnicas de bacteriología convencional. La resistencia a los antibióticos se determinó mediante el método de difusión con discos en agar y el gen mecA se detectó mediante reacción en cadena de la polimerasa. Se observó baja prevalencia de SAOR ...