In vitro radical-scavenging activity, toxicity against A. salina, and nmr profiles of extracts of lichens collected from Brazil and Antarctica

Extracts of six lichen species collected from Brazil and Antarctica were investigated for their potential toxicity and radical-scavenging properties. The composition of the extracts was investigated using TLC and NMR, leading to identification of atranorin (1), along with salazinic (2), barbatic (3)...

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Bibliographic Details
Published in:Química Nova
Main Authors: Luciana M. Ravaglia, Kerolayne Gonçalves, Nathália Mitsuko Oyama, Roberta Gomes Coelho, Adriano A. Spielmann, Neli K. Honda
Format: Article in Journal/Newspaper
Language:English
Spanish
Portuguese
Published: Sociedade Brasileira de Química 2014
Subjects:
lichens
phenolic compounds
NMR
radical-scavenging potential
Artemia salina
Chemistry
QD1-999
Antarc*
Antarctica
Online Access:https://doi.org/10.5935/0100-4042.20140159
https://doaj.org/article/f3c38f3a73344002b09b3537d376a033
Description
Summary:Extracts of six lichen species collected from Brazil and Antarctica were investigated for their potential toxicity and radical-scavenging properties. The composition of the extracts was investigated using TLC and NMR, leading to identification of atranorin (1), along with salazinic (2), barbatic (3), α-alectoronic (4), α-collatolic (5), cryptochlorophaeic (6), caperatic (7), lobaric (8), and protolichesterinic (9) acids. All acetone extracts were evaluated for their 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability and subjected to Artemia salina bioassay. The free-radical-scavenging activities of each extract (100 µg) ranged from 8.9 ± 0.1% to 38.7 ± 2.5% and the EC50 values ranged from 0.24 ± 2.10 to 3.54 ± 0.28 mg mL-1, while the toxicity of the extracts against A. salina were low (151.0 to >600 µg mL-1).

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